(Q24656054)

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Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model

scientific article published on December 1, 1993

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Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model (English)

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J. P. de Boer

1

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25 August 2024

A. A. Creasey

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7693593

25 August 2024

A. Chang

3

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25 August 2024

J. J. Abbink

4

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25 August 2024

D. Roem

5

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25 August 2024

A. J. Eerenberg

6

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25 August 2024

C. E. Hack

7

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25 August 2024

F. B. Taylor

8

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25 August 2024

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December 1993

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https://iai.asm.org/content/iai/61/12/5035.full.pdf

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25 August 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7693593/?tool=EBI

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25 August 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/7693593/pdf/?tool=EBI

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25 August 2024

http://iai.asm.org/cgi/content/abstract/61/12/5035

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25 August 2024

https://europepmc.org/articles/PMC281280

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7693593

25 August 2024

https://europepmc.org/articles/PMC281280?pdf=render

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7693593

25 August 2024

https://journals.asm.org/doi/pdf/10.1128/iai.61.12.5035-5043.1993

1 reference

10.1128/IAI.61.12.5035-5043.1993

https://api.crossref.org/works/10.1128/IAI.61.12.5035-5043.1993

25 August 2024

Infection and Immunity

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61

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12

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5035-43

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Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

7 April 2017

Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

7 April 2017

Activation of the complement system in baboons challenged with live Escherichia coli: correlation with mortality and evidence for a biphasic activation pattern

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Inactivation of kallikrein in human plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Alpha2-plasmin inhibitor and alpha2-macroglobulin-plasmin complexes in plasma. Quantitation by an enzyme-linked differential antibody immunosorbent assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Human plasma alpha 2-macroglobulin. An inhibitor of plasma kallikrein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Cachectin: more than a tumor necrosis factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

The pathogenesis of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Septic shock: pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Activation of the contact system in lethal hypotensive bacteremia in a baboon model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Purification of human plasma α2 macroglobulin and α1 proteinase inhibitor using zinc chelate chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Comparison of the inhibition of thrombin by three plasma protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Plasmin inhibitor interactions. The effectiveness of alpha2-plasmin inhibitor in the presence of alpha2-macroglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

The disappearance of enzyme-inhibitor complexes from the circulation of man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 September 2017

Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Evidence for similar conformational changes in α2-macroglobulin on reaction with primary amines or proteolytic enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Studies on human plasma alpha 2-macroglobulin-enzyme interactions. Evidence for proteolytic modification of the subunit chain structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Activation and inhibition of Hageman factor-dependent pathways and the complement system in uncomplicated bacteremia or bacterial shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Detection of the 'hyperdynamic state' of sepsis in the baboon during lethal E. coli infusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Activation patterns of coagulation and fibrinolysis in baboons following infusion with lethal or sublethal dose of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

30 May 2018

Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

19 June 2018

Covalent binding of proteinases in their reaction with α2-macroglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 November 2018

Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=281280

28 November 2018

MACROGLOBULIN FROM HUMAN PLASMA WHICH FORMS AN ENZYMATICALLY ACTIVE COMPOUND WITH TRYPSIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of125I-Trypsin α-Macroglobulin Complexes from Blood by Reticuloendothelial Cells in Dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoimmobilization of α2-macroglobulin-β-trypsin complexes: A novel approach for the biochemical characterization of modulator-protease interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A thiol-ester in α2-macroglobulin cleaved during proteinase complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of urokinase to plasma proteinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of human extrinsic (tissue-type) plasminogen activator in human plasma: no evidence for a specific inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on components of the plasma kallikrein-kinin system in plasma samples from normal individuals and patients with septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human factor Xa by various plasma protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nascent alpha 2-macroglobulin-trypsin complex: incorporation of amines and water at the thiol esterified Glx-residues of alpha 2-macroglobulin during activation with trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current perspective on the thiolester bond in alpha 2-macroglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predominant Role of Neutrophils in the Inactivation of α2-Macroglobulin in Arthritic Joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-macroglobulin binds and inhibits activated protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticoagulant and fibrinolytic activities are promoted, not retarded, in vivo after thrombin generation in the presence of a monoclonal antibody that inhibits activation of protein C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activation in vivo upon intravenous infusion of DDAVP. Quantitative assessment of plasmin-alpha 2-antiplasmin complex with a novel monoclonal antibody based radioimmunoassay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the relative contribution of different protease inhibitors to the inhibition of plasmin in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of association of human proteinases with human alpha 2-macroglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation and interactions of neutrophil elastase in haemostatic disorders of patients with severe infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization of serratial protease into cells as an enzyme-inhibitor complex with alpha 2-macroglobulin and regeneration of protease activity and cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma kallikrein-kinin system in patients with uncomplicated sepsis and septic shock--comparison with cardiogenic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of activation of the contact system of coagulation in vitro and in vivo: quantitation of activated Hageman factor-C-1-inhibitor and kallikrein-C-1-inhibitor complexes by specific radioimmunoassays

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of plasma proteases in septic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coagulation, fibrinolysis, and kallikrein systems in sepsis: relation to outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of functional and inactivated alpha 2-macroglobulin in sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-macroglobulin-kallikrein complexes detect contact system activation in hereditary angioedema and human sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7693593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.61.12.5035-5043.1993

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7693593

25 August 2024

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