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The localization and interactions of huntingtin
scientific article
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
The localization and interactions of huntingtin
(English)
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author name string
A L Jones
series ordinal
1
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language of work or name
English
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publication date
29 June 1999
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published in
Philosophical Transactions of the Royal Society B
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volume
354
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issue
1386
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page(s)
1021-7
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cites work
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin
1 reference
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PubMed Central
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7 April 2017
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
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7 April 2017
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
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PubMed Central
reference URL
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7 April 2017
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
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PubMed Central
reference URL
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7 April 2017
HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
7 April 2017
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats
1 reference
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PubMed Central
reference URL
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7 April 2017
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
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PubMed Central
reference URL
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7 April 2017
A huntingtin-associated protein enriched in brain with implications for pathology
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters
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PubMed Central
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7 April 2017
SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
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PubMed Central
reference URL
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7 April 2017
Huntingtin interacts with a family of WW domain proteins
1 reference
stated in
PubMed Central
reference URL
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7 April 2017
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
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7 April 2017
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Histone deacetylase activity is required for full transcriptional repression by mSin3A
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
What's up and down with histone deacetylation and transcription?
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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7 April 2017
HOMOCYSTINURIA: AN ENZYMATIC DEFECT.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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28 September 2017
Signal-specific co-activator domain requirements for Pit-1 activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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28 September 2017
A cellular model that recapitulates major pathogenic steps of Huntington's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
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28 September 2017
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Huntingtin interacts with cystathionine beta-synthase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
When more is less: pathogenesis of glutamine repeat neurodegenerative diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Psychiatric manifestations of homocystinuria due to cystathionine beta-synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Molecular analysis of cystathionine beta-synthase--a gene on chromosome 21.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Excitotoxic injury of the neostriatum: a model for Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 September 2017
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Huntingtin localization in brains of normal and Huntington's disease patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Fast transport and retrograde movement of huntingtin and HAP 1 in axons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Early loss of neostriatal striosome neurons in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Unusual sulfur-containing amino acids in the urine of homocystinuric patients: III. Homocysteic acid, homocysteine sulfinic acid, S-(carboxymethylthio) homocysteine, and S-(3-hydroxy-3-carboxy-n-propyl)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
l-Homocysteate stimulates [3H]MK-801 binding to the phencyclidine recognition site and is thus an agonist for the N-methyl-d-aspartate-operated cation channel
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
N-methyl-D-aspartate receptors and CNS symptoms of homocystinuria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
30 May 2018
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1692601
retrieved
28 November 2018
Biosynthesis and proteolytic activation of cystathionine beta-synthase in rat liver
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10434301
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Radioenzymic determination of homocysteine in plasma and urine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10434301
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1098%2FRSTB.1999.0454
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1098%2FRSTB.1999.0454
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1098%2FRSTB.1999.0454
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1098/RSTB.1999.0454
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PMCID
1692601
0 references
PubMed ID
10434301
0 references
ResearchGate publication ID
12866075
0 references
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