(Q24677312)

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Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale) (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Symphytum officinale

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1

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22 December 2019

author name string

Lei Guo

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Lu Zhang

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Leming Shi

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Yongming Andrew Sun

5

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22 December 2019

Chris Fung

6

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22 December 2019

Carrie L Moland

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Stacey L Dial

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

James C Fuscoe

9

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Tao Chen

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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6 September 2006

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22 December 2019

BMC Bioinformatics

2 references

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

7 Suppl 2

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22 December 2019

Suppl 2

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S16

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Europe PubMed Central

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22 December 2019

copyright license

Creative Commons Attribution 2.0 Generic

1 September 2006

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers

1 reference

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1 reference

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7 April 2017

Hepatic veno-occlusive disease associated with comfrey ingestion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

7 April 2017

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis

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7 April 2017

1 reference

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28 September 2017

Mutagenicity of comfrey (Symphytum Officinale) in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

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Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms

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Herbal bioactivation: the good, the bad and the ugly

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28 September 2017

Hepatic Veno-occlusive Disease (Sinusoidal Obstruction Syndrome) After Hematopoietic Stem Cell Transplantation

1 reference

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28 September 2017

Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Chemokines in liver inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

How nucleotide excision repair protects against cancer

1 reference

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28 September 2017

A mutator phenotype in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Hepatocyte growth factor: clinical implications in hepatobiliary pancreatic surgery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

The efficacy and safety of comfrey.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Pyrrolizidine alkaloids in human diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Immunohistochemical evaluation of Bcl-2 gene family expression in liver of hepatitis C and cirrhotic patients: a novel mechanism to explain the high incidence of hepatocarcinoma in cirrhotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Toxicity of comfrey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Induction of hepatic tumors in rats by senkirkine and symphytine

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28 September 2017

Carcinogenic activity of Symphytum officinale

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 September 2017

Analysis, separation, and bioassay of pyrrolizidine alkaloids from comfrey (Symphytum officinale).

1 reference

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28 September 2017

Statistical test for the comparison of samples from mutational spectra

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Deregulated cyclin E induces chromosome instability

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30 May 2018

Software for the analysis of mutations at the human hprt gene.

1 reference

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30 May 2018

Veno-occlusive disease of the liver secondary to ingestion of comfrey

1 reference

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30 May 2018

Comfrey herb tea-induced hepatic veno-occlusive disease

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The effects of comfrey derived pyrrolizidine alkaloids on rat liver.

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1 reference

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Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.

1 reference

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The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure.

1 reference

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Comfrey toxicity revisited

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1683566

28 November 2018

Comfrey herb tea and hepatic veno-occlusive disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malignant tumors in rats given lasiocarpine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of comfrey-pepsin preparations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activator inhibitor-1 confirms the diagnosis of hepatic veno-occlusive disease in patients with hyperbilirubinemia after bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a reproducible rat model of hepatic veno-occlusive disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic instability in Gadd45a-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2105-7-S2-S16

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

DBLP publication ID

journals/bmcbi/MeiGZSSFMDFC06

1 reference

DBLP Dataset 2021-01-02

28 January 2021

Dimensions Publication ID

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118137%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

ResearchGate publication ID

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