(Q24683592)

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The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH

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The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH (English)

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1 reference

based on heuristic

inferred from title

monoclonal antibody

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inferred from title

author name string

Yoshihiro Fukuoka

1

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Lawrence B Schwartz

2

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language of work or name

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publication date

1 March 2006

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Journal of Immunology

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176

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5

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3165-72

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Formation of active monomers from tetrameric human beta-tryptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

7 April 2017

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

7 April 2017

Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Human beta-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

MRI of the tumor microenvironment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Tryptase inhibition blocks airway inflammation in a mouse asthma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Endogenous airway acidification. Implications for asthma pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Human mast cell tryptase fibrinogenolysis: kinetics, anticoagulation mechanism, and cell adhesion disruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Inactivation of human lung tryptase: evidence for a re-activatable tetrameric intermediate and active monomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

The fibrinogenolytic activity of purified tryptase from human lung mast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 September 2017

Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Immunologic and physicochemical evidence for conformational changes occurring on conversion of human mast cell tryptase from active tetramer to inactive monomer. Production of monoclonal antibodies recognizing active tryptase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

The kininogenase activity of human mast cell tryptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

30 May 2018

Mast-cell infiltration of airway smooth muscle in asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 November 2018

Regulation of human mast cell beta-tryptase: conversion of inactive monomer to active tetramer at acid pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 November 2018

Human tryptase fibrinogenolysis is optimal at acidic pH and generates anticoagulant fragments in the presence of the anti-tryptase monoclonal antibody B12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 November 2018

Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 November 2018

Enzymatic properties of alpha 2-macroglobulin-proteinase complexes. Apparent discrimination between covalently and noncovalently bound trypsin by reaction with soybean trypsin inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810230

28 November 2018

Intraepithelial mast cells in allergic and nonallergic asthma. Assessment using bronchial brushings

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of alpha-2-macroglobulin as trypsin-protein esterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptase from human pulmonary mast cells. Purification and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled tryptase causes bronchoconstriction in sheep via histamine release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16493076

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.176.5.3165

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