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Autoregulation of the Raf-1 serine/threonine kinase
scientific article
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instance of
scholarly article
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title
Autoregulation of the Raf-1 serine/threonine kinase
(English)
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author name string
R E Cutler
series ordinal
1
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R M Stephens
series ordinal
2
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M R Saracino
series ordinal
3
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D K Morrison
series ordinal
4
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language of work or name
English
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publication date
4 August 1998
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published in
Proceedings of the National Academy of Sciences of the United States of America
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volume
95
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page(s)
9214-9
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issue
16
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cites work
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
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The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site
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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
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7 April 2017
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
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7 April 2017
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner
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PubMed Central
reference URL
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7 April 2017
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus
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7 April 2017
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus
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7 April 2017
Mammalian Ras interacts directly with the serine/threonine kinase Raf
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PubMed Central
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MAP kinase pathways in yeast: for mating and more
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7 April 2017
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
1 reference
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PubMed Central
reference URL
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7 April 2017
The complexity of Raf-1 regulation
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PubMed Central
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7 April 2017
Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras
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PubMed Central
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7 April 2017
Two distinct Raf domains mediate interaction with Ras
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PubMed Central
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7 April 2017
Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1
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PubMed Central
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7 April 2017
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
1 reference
stated in
PubMed Central
reference URL
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7 April 2017
Multiple regulatory domains on the Byr2 protein kinase
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PubMed Central
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28 September 2017
Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila
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PubMed Central
reference URL
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28 September 2017
Taxonomy and function of C1 protein kinase C homology domains
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PubMed Central
reference URL
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28 September 2017
Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells
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PubMed Central
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28 September 2017
Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development
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28 September 2017
Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
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PubMed Central
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28 September 2017
The 3Rs of life: Ras, Raf and growth regulation
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PubMed Central
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28 September 2017
The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras.
1 reference
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PubMed Central
reference URL
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28 September 2017
Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP.
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PubMed Central
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28 September 2017
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction
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PubMed Central
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28 September 2017
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer
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PubMed Central
reference URL
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28 September 2017
Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences
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PubMed Central
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28 September 2017
Rat c-raf oncogene activation by a rearrangement that produces a fused protein
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PubMed Central
reference URL
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28 September 2017
B-raf, a new member of the raf family, is activated by DNA rearrangement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
retrieved
28 September 2017
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
Definition of the human raf amino-terminal regulatory region by deletion mutagenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
Mutational activation of c-raf-1 and definition of the minimal transforming sequence
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
The Raf-1 kinase as a transducer of mitogenic signals
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
Regulation of protein kinase C.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 September 2017
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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30 May 2018
A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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30 May 2018
Identification of the major phosphorylation sites of the Raf-1 kinase.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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30 May 2018
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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30 May 2018
The ins and outs of Raf kinases
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Crossref
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https://api.crossref.org/works/10.1073%2FPNAS.95.16.9214
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21 January 2018
The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype.
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28 November 2018
A mechanism of c-raf-1 activation: fusion of the lipocortin II amino-terminal sequence with the c-raf-1 kinase domain.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21318
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28 November 2018
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo
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Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.95.16.9214
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21 January 2018
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.95.16.9214
retrieved
7 January 2021
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Identifiers
DOI
10.1073/PNAS.95.16.9214
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ADS bibcode
1998PNAS...95.9214C
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PMCID
21318
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PubMed ID
9689060
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ResearchGate publication ID
13596283
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