(Q24800095)

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Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53

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Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53 (English)

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apoptotic process

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1 reference

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author name string

Jihan A Youssef

1

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Mostafa Z Badr

2

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publication date

3 January 2003

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Molecular Cancer

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2

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1

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3

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Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.

1 reference

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7 April 2017

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

7 April 2017

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

1 reference

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7 April 2017

HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

1 reference

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7 April 2017

Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone

1 reference

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7 April 2017

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

7 April 2017

Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto-oncogenes in normal human osteoblast-like cells

1 reference

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7 April 2017

Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

7 April 2017

Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Effects of antiprogestins RU486 and ZK98299 on the expression of cell cycle proteins of a medroxyprogesterone acetate (MPA)-induced murine mammary tumor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

RU486-induced growth inhibition of human endometrial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Lipopolysaccharide-induced desensitization of junB gene expression in a mouse macrophage-like cell line, P388D1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Induction of apoptosis by the c-Myc helix-loop-helix/leucine zipper domain in mouse 3T3-L1 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

RU486 (mifepristone): mechanisms of action and clinical uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Circadian synchronization of hepatocyte proliferation in young rats: the role played by adrenal hormones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 September 2017

Overexpression of JunB in undifferentiated malignant rat oral keratinocytes enhances the malignant phenotype in vitro without altering cellular differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

30 May 2018

Will Canada follow US lead on RU 486?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

30 May 2018

RU 486 (mifepristone). A short overview of its mechanisms of action and clinical uses at the end of 1996.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

30 May 2018

Effect of RU 38486 on TNF production and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

30 May 2018

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

1 reference

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28 November 2018

Involvement of c-myc in the resistance of non-obese diabetic mice to glucocorticoid-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149417

28 November 2018

Inhibition of proliferation and differentiation by RU 486 in human endometrial stromal and epithelial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone inhibits antitumor potential of activated macrophages by a receptor mediated action

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of liver cell proliferation by glucocorticoid hormone: a comparison of normally growing and regenerating tissue in the immature rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid regulation of transcription of the c-myc cellular protooncogene in P1798 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mifepristone (RU 486): Rationale and Use in Cancer Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of Liver DNA Synthesis by Cortisone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12605714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-2-3

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