(Q24802851)

5 July 2017

title

PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol (English)

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5 July 2017

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David G Levitt

1

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5 July 2017

language of work or name

English

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publication date

15 August 2002

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BMC Clinical Pharmacology

5 July 2017

published in

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5 July 2017

volume

2

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5 July 2017

issue

1

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page(s)

5

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Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age, somatotype and habits of physical activity on the variance after regression of volumes to height and weight combined

5 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

The measurement of total body water in the human subject by deuterium oxide dilution; with a consideration of the dynamics of deuterium distribution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Total body water reference values and prediction equations for adults

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Appropriate use and misuse of blood concentration measurements to quantitate first-pass metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Correlation between ventilation and perfusion determines VA/Q heterogeneity in endotoxemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Pharmacokinetics of beta-adrenoceptor blockers in obese and normal volunteers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Unaltered serum propranolol binding by meal-induced variations in fatty acids

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Continuous Distributions of Ventilation-Perfusion Ratios in Normal Subjects Breathing Air and 100% O2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Reference values for resting blood flow to organs of man.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Food effects on propranolol systemic and oral clearance: support for a blood flow hypothesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Quantitative account of propranolol metabolism in urine of normal man.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Determination of inulin clearance by bolus intravenous injection in healthy subjects and ascitic patients: equivalence of systemic and renal clearances as glomerular filtration markers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

A physiologic pharmacokinetic model for styrene and styrene-7,8-oxide in mouse, rat and man.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Early kinetics of intravenous propranolol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Linear and nonlinear system approaches in pharmacokinetics: how much do they have to offer? I. General considerations.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Effect of meal on portal hemodynamics in healthy humans and in patients with chronic liver disease.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Gastrointestinal absorption of xenobiotics in physiologically based pharmacokinetic models. A two-compartment description

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Some fundamental considerations of the applications of pharmacokinetics to cancer chemotherapy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Studies on the uptake and binding of propranolol by rat tissues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Diffusion-limited, but not perfusion-limited, compartmental models describe cerebral nitrous oxide kinetics at high and low cerebral blood flows

30 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-2-5

Physiologically based modeling of the inhalation kinetics of styrene in humans using a bayesian population approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-2-5

A fast annealing evolutionary algorithm for global optimization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-2-5

Contributions of pulmonary perfusion and ventilation to heterogeneity in V(A)/Q measured by PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-2-5

A pharmacokinetic model describing pulsatile uptake of orally-administered carbon tetrachloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6904-2-5

Effects of fasting and chronic alcohol consumption on the first-pass metabolism of ethanol.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=126244

Enhancement of the bioavailability of propranolol and metoprolol by food

28 November 2018

1 reference

12 December 2020

Liver function assessed by increased rate of portal venous blood flow after oral intake of glucose

1 reference

12 December 2020

Contributions of ventilation and perfusion inhomogeneities to the VA/Q distribution

1 reference

12 December 2020

Pharmacokinetics of propranolol

1 reference

12 December 2020

Stereoselective clearance and distribution of intravenous propranolol

1 reference

12 December 2020

Use of the deconvolution principle in the estimation of absorption and pre-systemic intestinal elimination of drugs

1 reference

12 December 2020

Portal hemodynamics after meal in normal subjects and in patients with chronic liver disease studied by echo-Doppler flowmeter

1 reference

12 December 2020

Intestinal absorption and presystemic elimination of the prokinetic agent, EM574, in the rabbit

1 reference

12 December 2020

Body composition measurements in normal man: the potassium, sodium, sulfate and tritium spaces in 58 adults

1 reference

12 December 2020

Dose-dependent elimination of propranolol and its major metabolites in humans

1 reference

12 December 2020

Biological determinants of propranolol disposition in man

1 reference

12 December 2020

A propranolol radioimmunoassay and its use in the study of its pharmaco‐kinetics following low doses

1 reference

12 December 2020

Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly

1 reference

12 December 2020

Intrahepatic distribution of hepatic blood flow: single-input studies

1 reference

12 December 2020

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

1 reference

12 December 2020

Relation of blood volume and cardiac output to body type.

1 reference

12 December 2020

No stereoselective first-pass hepatic extraction of propranolol

1 reference

12 December 2020

Decreased absorption as a possible cause for the lower bioavailability of a sustained-release propranolol

1 reference

12 December 2020

Food-induced increase in propranolol bioavailability—Relationship to protein and effects on metabolites

1 reference

12 December 2020

The pharmacokinetics of etretinate and its metabolites in the dog

1 reference

12 December 2020

Propranolol binding in serum: comparison of methods and investigation of effects of drug concentration, pH, and temperature

1 reference

12 December 2020

Intrahepatic distribution of hepatic blood flow: double-input studies

1 reference

12 December 2020

Identifiers

DOI

10.1186/1472-6904-2-5

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Dimensions Publication ID

5 July 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1472-6904-2-5

PMC publication ID

126244

1 reference

5 July 2017

1 reference