(Q24805749)

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Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

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Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor (English)

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author name string

Johanna Westra

1

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Berber Doornbos-van der Meer

2

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Peter de Boer

3

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Miek A van Leeuwen

4

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Martin H van Rijswijk

5

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Pieter C Limburg

6

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language of work or name

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publication date

2004

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Arthritis Research and Therapy

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6

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4

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R384-92

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Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

7 April 2017

MAP kinase activation in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

7 April 2017

Macrophages in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

7 April 2017

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

7 April 2017

Rheumatoid arthritis therapy after tumor necrosis factor and interleukin-1 blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Therapeutic strategies for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Matrix metalloproteinases in arthritic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Cytokine pathways and joint inflammation in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

HLA molecules, bacteria and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Analysis of the IFN-gamma-signaling pathway in macrophages at different stages of maturation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Accelerated generation of CD14+ monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 September 2017

Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

30 May 2018

Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=464924

28 November 2018

Low serum conditions for in vitro generation of human macrophages with macrophage colony stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synovial tissue macrophage populations and articular damage in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthr

1 reference

https://pubmed.ncbi.nlm.nih.gov/15225374

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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