(Q26768661)

The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies

PubMed

volume

76

0 references

issue

2

0 references

page(s)

164-169

0 references

cites work

1 reference

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7 April 2017

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A phase II evaluation of the potent, highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation - An

7 April 2017

1 reference

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Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study

7 April 2017

1 reference

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Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

7 April 2017

1 reference

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

7 April 2017

1 reference

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Integrated genomic analyses of ovarian carcinoma

7 April 2017

1 reference

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

7 April 2017

1 reference

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PARP inhibition: PARP1 and beyond

7 April 2017

1 reference

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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial.

7 April 2017

1 reference

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Appraising iniparib, the PARP inhibitor that never was--what must we learn?

28 September 2017

1 reference

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The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

28 September 2017

1 reference

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A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer

28 September 2017

1 reference

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Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer

28 September 2017

1 reference

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Molecular pathways: targeting PARP in cancer treatment

28 September 2017

1 reference

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

28 September 2017

1 reference

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Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

28 September 2017

1 reference

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Olaparib, PARP1 inhibitor in ovarian cancer.

28 September 2017

1 reference

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A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas

28 September 2017

1 reference

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The DNA damage response and cancer therapy

28 September 2017

1 reference

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Phase I study to assess the safety and tolerability of olaparib in combination with bevacizumab in patients with advanced solid tumours

28 September 2017

1 reference

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Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas

28 September 2017

1 reference

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.

28 September 2017

1 reference

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

28 September 2017

1 reference

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Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors

28 September 2017

1 reference

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Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

28 September 2017

1 reference

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BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4771499

Veliparib plus temozolomide in metastatic melanoma trends toward increased PFS but results are not statistically significant

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26941449

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26941449