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CD4+/CD8+ double-positive T cells: more than just a developmental stage?
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PubMed
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Europe PubMed Central
title
CD4+/CD8+ double-positive T cells: more than just a developmental stage?
(English)
1 reference
stated in
PubMed
author
Nana H. Overgaard
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
Raymond J Steptoe
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
author name string
Ji-Won Jung
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
James W Wells
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
language of work or name
English
1 reference
stated in
PubMed
publication date
January 2015
1 reference
stated in
PubMed
published in
Journal of Leukocyte Biology
2 references
stated in
PubMed
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
volume
97
2 references
stated in
PubMed
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
issue
1
2 references
stated in
PubMed
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
page(s)
31-38
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
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Co-expression of CD8 alpha in CD4+ T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer.
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A novel peripheral CD4+ CD8+ T cell population: inheritance of CD8alpha expression on CD4+ T cells
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CD8 alpha is an activation marker for a subset of peripheral CD4 T cells
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7 January 2021
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Increased frequency of nonconventional double positive CD4CD8 alphabeta T cells in human breast pleural effusions.
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7 January 2021
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Tumor-reactive CD4+ CD8αβ+ CD103+ αβT cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers.
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7 January 2021
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Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with human T cell leukemia virus type I (HTLV-I).
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Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging
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7 January 2021
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Phenotypic heterogeneity of persistent expansions of CD4+ CD8+ T cells
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7 January 2021
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Role of IL-13 in regulation of anti-tumor immunity and tumor growth
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7 January 2021
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CD4+ CD8+ cells are rare among in vitro activated mouse or human T lymphocytes
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7 January 2021
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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
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7 January 2021
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CD4+ CD8+ double positive (DP) T cells in health and disease
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7 January 2021
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Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8+ T-cells.
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7 January 2021
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Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer
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7 January 2021
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The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
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7 January 2021
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The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
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7 January 2021
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CD4, CD8 and TCR defined T-cell subsets in thymus and spleen of 2- and 7-week old commercial broiler chickens
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7 January 2021
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Extrathymic CD4/CD8 double positive T cells
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
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7 January 2021
based on heuristic
inferred from DOI database lookup
Co-expression of the CD8 receptor in a human CD4+ T-cell clone influences proliferation, cytosolic Ca2+ release and cytokine production
1 reference
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Crossref
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https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
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7 January 2021
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Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells
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Crossref
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7 January 2021
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NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
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7 January 2021
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The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival
1 reference
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Crossref
reference URL
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7 January 2021
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ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
1 reference
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Crossref
reference URL
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7 January 2021
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Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity
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Crossref
reference URL
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7 January 2021
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Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
T-cell development and the CD4-CD8 lineage decision
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD4+ CD8+ (thymocyte-like) T lymphocytes present in blood and skin from patients with atopic dermatitis suggest immune dysregulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional and phenotypic analysis of porcine peripheral blood CD4/CD8 double-positive T cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phenotypic analysis of peripheral CD4+ CD8+ T cells in the rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Age-related increase of peripheral CD4+ CD8+ double-positive T lymphocytes in cynomolgus monkeys: longitudinal study in relation to thymic involution.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An important regulatory role for CD4 + CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An immunoregulatory function for the CD8 molecule
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripheral blood CD4+CD8+ lymphocytes in cynomolgus monkeys are of resting memory T lineage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4dullCD8bright double-positive T-lymphocytes have a phenotype of granzyme Bpos CD8pos memory T-lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epicutaneous immunization induces alphabeta T-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factor-beta.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of CD8alpha identifies a distinct subset of effector memory CD4+ T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expansion of a novel pulmonary CD3(-) CD4(+) CD8(+) cell population in mice during Chlamydia pneumoniae infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripheral NKT cells in simian immunodeficiency virus-infected macaques
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Simian immunodeficiency virus infection of CD8+ lymphocytes in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of T cell development and transformation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive and negative selection of T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of ThPOK in control of CD4/CD8 lineage commitment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased CD4+/CD8+ double-positive T cells in chronic Chagasic patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Double positive CD4CD8 alphabeta T cells: a new tumor-reactive population in human melanomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct CD4+ CD8+ double-positive T cells in the blood and liver of patients during chronic hepatitis B and C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The presence of CD8+ invariant NKT cells in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation of human CD4/CD8 double-positive, graft-versus-host disease-protective, minor histocompatibility antigen-specific regulatory T cells and of a novel HLA-DR7-restricted HY-specific CD4 clone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rat peripheral CD4+CD8+ T lymphocytes are partially immunocompetent thymus-derived cells that undergo post-thymic maturation to become functionally mature CD4+ T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1189%2FJLB.1RU0814-382
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1189/JLB.1RU0814-382
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124617
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
OpenCitations bibliographic resource ID
124617
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124617
PubMed publication ID
25360000
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124617
stated in
Europe PubMed Central
PubMed publication ID
25360000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25360000%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 June 2020
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