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CAR T cells for solid tumors: armed and ready to go?
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PubMed
title
CAR T cells for solid tumors: armed and ready to go?
(English)
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stated in
PubMed
author name string
Sunitha Kakarla
series ordinal
1
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Crossref
Stephen Gottschalk
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
2014
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PubMed
published in
The Cancer Journal
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stated in
PubMed
volume
20
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
151-5
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stated in
PubMed
cites work
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Tumor Immunotherapy Directed at PD-1
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Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
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B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
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Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
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7 April 2017
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
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7 April 2017
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
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PubMed Central
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Immunosuppressive strategies that are mediated by tumor cells
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Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
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Reassessing target antigens for adoptive T-cell therapy
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Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity.
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Gene-engineered T cells for cancer therapy
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PubMed Central
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TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy
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PubMed Central
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Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma
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PubMed Central
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28 September 2017
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
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Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.
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28 September 2017
Collapse of the tumor stroma is triggered by IL-12 induction of Fas.
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PubMed Central
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28 September 2017
The basic principles of chimeric antigen receptor design
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PubMed Central
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28 September 2017
Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity
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PubMed Central
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Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
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28 September 2017
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
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28 September 2017
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
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Interleukin 15 provides relief to CTLs from regulatory T cell-mediated inhibition: implications for adoptive T cell-based therapies for lymphoma
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Targeting of a conformationally exposed, tumor-specific epitope of EGFR as a strategy for cancer therapy
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PubMed Central
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Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling.
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A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor
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Epigenetic modulation to enable antigen-specific T-cell therapy of colorectal cancer
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PubMed Central
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Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
1 reference
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PubMed Central
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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
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PubMed Central
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Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment
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PubMed Central
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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
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PubMed Central
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Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
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PubMed Central
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T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.
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PubMed Central
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Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.
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PubMed Central
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Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.
1 reference
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PubMed Central
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TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression
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PubMed Central
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PubMed Central
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CAR mechanics: driving T cells into the MUC of cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.
1 reference
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PubMed Central
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28 September 2017
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Immune resistance orchestrated by the tumor microenvironment
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
retrieved
28 September 2017
Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
retrieved
28 September 2017
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 September 2017
Genetic treatment of the haemoglobinopathies: recombinations and new combinations
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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31 May 2018
Differential EphA2 epitope display on normal versus malignant cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 November 2018
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050065
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28 November 2018
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24667962
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24667962
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24667962
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1097/PPO.0000000000000032
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1486815
Fatcat ID
release_s2zlhbwgvrftlgqufsbny42yxi
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/s2zlhbwgvrftlgqufsbny42yxi
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
1486815
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1486815
PMC publication ID
4050065
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1486815
PubMed publication ID
24667962
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1486815
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