(Q26830817)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

review article

1 reference

title

The FHIT gene product: tumor suppressor and genome "caretaker" (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author name string

Seyed Ali Hosseini

series ordinal

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Kay Huebner

series ordinal

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Catherine E Waters

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

language of work or name

1 reference

5 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

20 February 2020

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

71

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

23

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

4577-4587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

Mutational processes molding the genomes of 21 breast cancers

20 February 2020

cites work

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Detectable clonal mosaicism and its relationship to aging and cancer

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Hallmarks of Cancer: The Next Generation

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Human cancers express a mutator phenotype

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

The tumor spectrum in FHIT-deficient mice

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Muir-Torre-like syndrome in Fhit-deficient mice

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Evolution of the cancer genome

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Initiation of genome instability and preneoplastic processes through loss of Fhit expression

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Detectable clonal mosaicism from birth to old age and its relationship to cancer

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Genomic instability--an evolving hallmark of cancer

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Genome instability: a mechanistic view of its causes and consequences

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

19 March 2017

Chromosome fragile sites

2 references

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Nucleotide metabolism, oncogene-induced senescence and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Microhomology directs diverse DNA break repair pathways and chromosomal translocations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Recovery of arrested replication forks by homologous recombination is error-prone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

dNTP pools determine fork progression and origin usage under replication stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Human cancers express mutator phenotypes: origin, consequences and targeting

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Break-induced replication is highly inaccurate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Mutator phenotype in cancer: origin and consequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Pathology and biology associated with the fragile FHIT gene and gene product

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fhit regulates invasion of lung tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

On the karyotypic origin and evolution of cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fragile gene product, Fhit, in oxidative and replicative stress responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Genetic instability is not a requirement for tumor development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

An oncogene-induced DNA damage model for cancer development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Many roads lead to oncogene-induced senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Replication stress induces tumor-like microdeletions in FHIT/FRA3B

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Intrinsic tumour suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

DNA damage in folate deficiency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Ddb1 controls genome stability and meiosis in fission yeast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

An FHIT tumor suppressor gene?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Constitutive fragile sites and cancer.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Different genetic pathways in the development of periocular sebaceous gland carcinomas in presumptive Muir-Torre syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Concordant loss of fragile gene expression early in breast cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynx

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

FHIT expression in neoplastic, hyperplastic, and normal endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

FRA3B and other common fragile sites: the weakest links

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

RORA, a large common fragile site gene, is involved in cellular stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Anaphase Onset Before Complete DNA Replication with Intact Checkpoint Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1722-0

Abnormal Fhit expression in malignant and premalignant lesions of the cervix.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4233150

Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus

28 November 2018

1 reference

12 December 2020

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands

1 reference

12 December 2020

Clonal genetic alterations in the lungs of current and former smokers

1 reference

12 December 2020

FHIT gene transcript alterations occur frequently in myeloproliferative and myelodysplastic diseases

1 reference

12 December 2020

Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas

1 reference

12 December 2020

The role of the FHIT/FRA3B locus in cancer

1 reference

12 December 2020

Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus

1 reference

12 December 2020

Loss of FHIT function in lung cancer and preinvasive bronchial lesions

1 reference

12 December 2020

10.1007/S00018-014-1722-0

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

1006769216

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25283145%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

25283145

2 references