(Q26850196)

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A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation

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A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation (English)

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Heart failure with preserved ejection fraction

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ejection fraction

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author name string

Walter J. Paulus

1

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Carsten Tschöpe

2

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language of work or name

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publication date

23 July 2013

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Journal of the American College of Cardiology

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62

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4

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263-71

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Heart failure with preserved ejection fraction: treat now by treating comorbidities

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Contribution of comorbidities to functional impairment is higher in heart failure with preserved than with reduced ejection fraction

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Left ventricular adaptation to chronic pressure overload induced by inhibition of nitric oxide synthase in rats

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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ACE inhibition and endothelial function: main findings of PERFECT, a sub-study of the EUROPA trial

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension.

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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The role of leukocyte-generated oxidants in left ventricular remodeling

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial.

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Treatment of heart failure with normal ejection fraction: an inconvenient truth!

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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The aging process of the heart: obesity is the main risk factor for left atrial enlargement during aging the MONICA/KORA (monitoring of trends and determinations in cardiovascular disease/cooperative research in the region of Augsburg) study

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

New targets to treat the structural remodeling of the myocardium

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

What have we learned about patients with heart failure and preserved ejection fraction from DIG-PEF, CHARM-preserved, and I-PRESERVE?

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Endothelial dysfunction: a pathophysiologic factor in heart failure with preserved ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Peroxynitrite Increases Protein Phosphatase Activity and Promotes the Interaction of Phospholamban with Protein Phosphatase 2a in the Myocardium.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of nitric oxide in the failing heart

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Understanding "diastolic" heart failure

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy, redox signaling, and ventricular remodeling

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Haemodynamic, neuroendocrine and metabolic correlates of circulating cytokine concentrations in congestive heart failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Inflammation and metabolic dysfunction: links to cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between oxidative stress and inflammation in salt-sensitive hypertension.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiomyocyte Stiffness in Diastolic Heart Failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Load versus humoral activation in the genesis of early hypertensive heart disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

NAD(P)H oxidase: role in cardiovascular biology and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical characteristics of pulmonary hypertension in patients with heart failure and preserved ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Body mass index and adverse cardiovascular outcomes in heart failure patients with preserved ejection fraction: results from the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Diastolic Stiffness of the Failing Diabetic Heart

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

The progression of hypertensive heart disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Passive stiffness of myocardium from congenital heart disease and implications for diastole.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac titin: a multifunctional giant

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular inflammation in obesity and sleep apnea

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Circulating biomarkers of collagen metabolism in cardiac diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT).

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Obesity and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure with preserved ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress and apoptosis in heart failure progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Prognostic utility of ST2 in patients with acute dyspnea and preserved left ventricular ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

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