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Dynorphin--still an extraordinarily potent opioid peptide
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PubMed
title
Dynorphin--still an extraordinarily potent opioid peptide
(English)
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stated in
PubMed
main subject
opioid
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dynorphin
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author name string
C. Chavkin
series ordinal
1
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
April 2013
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stated in
PubMed
published in
Molecular Pharmacology
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stated in
PubMed
volume
83
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PubMed
issue
4
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stated in
PubMed
page(s)
729-36
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PubMed
cites work
Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation
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Dynorphin, stress, and depression
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21 March 2017
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system
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21 March 2017
Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence
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21 March 2017
Functional Selectivity and Classical Concepts of Quantitative Pharmacology
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21 March 2017
Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system
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21 March 2017
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses
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21 March 2017
G-protein-coupled receptor heterodimerization modulates receptor function
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21 March 2017
Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain
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21 March 2017
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands
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21 March 2017
Dynorphin-(1-13), an extraordinarily potent opioid peptide
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PubMed Central
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21 March 2017
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
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21 March 2017
Psychotomimesis mediated by kappa opiate receptors
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21 March 2017
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog
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21 March 2017
Stress and the brain: from adaptation to disease
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7 April 2017
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake
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PubMed Central
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28 September 2017
The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety
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28 September 2017
κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal
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28 September 2017
mRNA transcript diversity creates new opportunities for pharmacological intervention
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28 September 2017
Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference
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PubMed Central
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28 September 2017
Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer
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28 September 2017
Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction
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28 September 2017
Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
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28 September 2017
Exploring a role for heteromerization in GPCR signalling specificity
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28 September 2017
Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms
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28 September 2017
Kinase cascades and ligand-directed signaling at the kappa opioid receptor
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28 September 2017
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
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28 September 2017
30 years of dynorphins--new insights on their functions in neuropsychiatric diseases
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28 September 2017
Dynorphin A activates bradykinin receptors to maintain neuropathic pain
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28 September 2017
Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model
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28 September 2017
Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist
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28 September 2017
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats
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28 September 2017
Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems.
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28 September 2017
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.
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28 September 2017
The complete amino acid sequence of alpha-neo-endorphin
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28 September 2017
Endogenous Opioids: Biology and Function
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28 September 2017
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
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PubMed Central
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28 September 2017
Interconverting mu and delta forms of the opiate receptor in rat striatal patches
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28 September 2017
Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors
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28 September 2017
Dynorphin converting enzyme with unusual specificity from rat brain
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28 September 2017
Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus
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28 September 2017
Rimorphin, a unique, naturally occurring [Leu]enkephalin-containing peptide found in association with dynorphin and alpha-neo-endorphin
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PubMed Central
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28 September 2017
Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary
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28 September 2017
Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor
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28 September 2017
Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide
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28 September 2017
Specific receptor for the opioid peptide dynorphin: structure--activity relationships
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28 September 2017
Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus
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28 September 2017
Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists
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PubMed Central
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28 September 2017
Identification of two related pentapeptides from the brain with potent opiate agonist activity
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28 September 2017
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin
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28 September 2017
Kinetics of opiate receptor inactivation by sulfhydryl reagents: evidence for conformational change in presence of sodium ions
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28 September 2017
Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor
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28 September 2017
6.beta.-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5.alpha.-epoxy-3,14-dihydroxymorphinan (chloranaltrexamine), a potent opioid receptor alkylating agent with ultralong narcotic antagonist activity
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28 September 2017
Endogenous opioid peptides: multiple agonists and receptors
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28 September 2017
Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors).
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28 September 2017
Endogenous opioid regulation of hippocampal function
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28 September 2017
The therapeutic potential of κ-opioids for treatment of pain and addiction
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31 May 2018
Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters.
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31 May 2018
Dynorphin-A-(1-8) is contained within vasopressin neurosecretory vesicles in rat pituitary.
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31 May 2018
Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea
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31 May 2018
Evidence that dynorphin-(1–13) acts as an agonist on opioid κ-receptors
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31 May 2018
Activation of K-opiate sites by dynorphin in the myenteric plexus
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PubMed Central
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31 May 2018
Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor
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31 May 2018
Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor
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31 May 2018
The preference of putative pro-enkephalins for different types of opiate receptors
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31 May 2018
Dynorphin. Nathan B. Eddy memorial award lecture
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31 May 2018
The sensitivity of opioid receptor types to regulation by sodium and GTP
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31 May 2018
Conversion of leumorphin (dynorphin B-29) to dynorphin B and dynorphin B-14 by thiol protease activity.
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31 May 2018
Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus
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31 May 2018
A peptide-like substance from pituitary that acts like morphine. I. Isolation.
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31 May 2018
A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties
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31 May 2018
α-Neo-endorphin: A “big” leu-enkephalin with potent opiate activity from porcine hypothalami
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31 May 2018
Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors
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28 November 2018
Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity
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28 November 2018
Nicotine withdrawal and kappa-opioid receptors.
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28 November 2018
Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Defective prodynorphin processing in mice lacking prohormone convertase PC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Characterizing the site and mode of action of dynorphin at hippocampal mossy fiber synapses in the guinea pig.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fibre synapses and modulates long-term potentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Opioid receptor selectivity of dynorphin gene products
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
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28 November 2018
Nonopiate effects of dynorphin and des-Tyr-dynorphin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Dynorphins: similar relative potencies on mu, delta- and kappa-opiate receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608442
retrieved
28 November 2018
Highly specific opiate receptors for dynorphin-(1–13) in the mouse vas deferens
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential effects of potassium on the potency of different opioids in the mouse vas deferens
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dynorphin interaction at the κ-opiate site
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endogenous ligands for κ-opiate receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Opiate activity and receptor selectivity of dynorphin1–13 and related peptides
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Affinity of normorphine for its pharmacologic receptor in the naive and morphine-tolerant guinea-pig isolated ileum
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A dynorphinergic pathway of Leu-enkephalin production in rat substantia nigra
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthetic analgesics: stereochemical considerations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Stress-induced relapse to heroin and cocaine seeking in rats: a review
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23152558
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1124/MOL.112.083337
0 references
PMC publication ID
3608442
1 reference
stated in
PubMed
PubMed publication ID
23152558
1 reference
stated in
PubMed
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