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Testing the right target and right drug at the right stage
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scholarly article
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PubMed
title
Testing the right target and right drug at the right stage
(English)
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PubMed
author name string
R. A. Sperling
series ordinal
1
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C. R. Jack
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P. S. Aisen
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3
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language of work or name
English
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PubMed
publication date
30 November 2011
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published in
Science Translational Medicine
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PubMed
volume
3
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PubMed
page(s)
111cm33
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PubMed
issue
111
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cites work
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
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An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
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Resolving controversies on the path to Alzheimer's therapeutics
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28 September 2017
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup
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28 September 2017
Amyloid-dependent and amyloid-independent stages of Alzheimer disease
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28 September 2017
Amyloid-β associated cortical thinning in clinically normal elderly
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28 September 2017
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
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28 September 2017
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
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28 September 2017
Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
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PubMed Central
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28 September 2017
Cognition, reserve, and amyloid deposition in normal aging
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PubMed Central
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28 September 2017
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
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28 September 2017
Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
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28 September 2017
Amyloid deposition is associated with impaired default network function in older persons without dementia
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PubMed Central
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28 September 2017
MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations
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PubMed Central
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28 September 2017
Amyloid imaging in mild cognitive impairment subtypes.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
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28 September 2017
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
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28 September 2017
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
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PubMed Central
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28 September 2017
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
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PubMed Central
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28 September 2017
Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
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PubMed Central
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28 September 2017
Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
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28 September 2017
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
retrieved
28 September 2017
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
retrieved
31 May 2018
PET imaging of amyloid deposition in patients with mild cognitive impairment.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
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31 May 2018
Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study.
1 reference
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Crossref
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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Biochemical markers in persons with preclinical familial Alzheimer disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Abeta species removal after abeta42 immunization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002609
retrieved
21 January 2018
Episodic memory decline predicts cortical amyloid status in community-dwelling older adults.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
retrieved
28 November 2018
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3752906
retrieved
28 November 2018
Identifiers
DOI
10.1126/SCITRANSLMED.3002609
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
274571
OpenCitations bibliographic resource ID
274571
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
274571
PMCID
3752906
1 reference
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PubMed
PubMed ID
22133718
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PubMed
ResearchGate publication ID
51846063
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