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Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁)
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scholarly article
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title
Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁)
(English)
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author name string
Dafydd R. Owen
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
17 August 2011
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stated in
PubMed
published in
ACS Chemical Neuroscience
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stated in
Crossref
volume
2
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stated in
PubMed
issue
8
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PubMed
page(s)
394-401
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PubMed
cites work
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
21 March 2017
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
21 March 2017
Pharmacology and functions of metabotropic glutamate receptors
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
7 April 2017
Searching chemical space with the Bayesian Idea Generator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Allosteric modulators for mGlu receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Positive and negative modulation of group I metabotropic glutamate receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Molecular determinants of metabotropic glutamate receptor signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 September 2017
A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
From pyrroles to pyrrolo[1,2-a]pyrazinones: a new class of mGluR1 antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3369754
retrieved
28 November 2018
Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22860168
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthesis and Preliminary Biological Evaluation of 2′-Substituted 2-(3′-Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22860168
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure–Activity Relationship Investigations for Coumarine Derivatives
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22860168
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22860168
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/CN2000124
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PMC publication ID
3369754
1 reference
stated in
PubMed
PubMed publication ID
22860168
1 reference
stated in
PubMed
ResearchGate publication ID
230617047
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