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PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis
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PubMed
title
PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis
(English)
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author name string
M. Zigler
series ordinal
1
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Crossref
T. Kamiya
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2
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E. C. Brantley
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3
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G. J. Villares
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4
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M. Bar-Eli
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5
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language of work or name
English
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stated in
PubMed
publication date
1 November 2011
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PubMed
published in
Cancer Research
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stated in
PubMed
volume
71
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PubMed
issue
21
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PubMed
page(s)
6561-6
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PubMed
cites work
Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis
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PubMed Central
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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
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21 March 2017
Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
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PubMed Central
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21 March 2017
Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
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PubMed Central
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21 March 2017
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
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Thrombin signalling and protease-activated receptors
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PubMed Central
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7 April 2017
The emerging role of the thrombin receptor (PAR-1) in melanoma metastasis--a possible therapeutic target
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PubMed Central
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28 September 2017
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
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PubMed Central
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28 September 2017
Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
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28 September 2017
Thrombin receptor antagonism -the potential of antiplatelet medication SCH 530348.
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PubMed Central
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28 September 2017
Thrombin's central role in angiogenesis and pathophysiological processes
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PubMed Central
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28 September 2017
Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype
1 reference
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PubMed Central
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28 September 2017
Thrombin-activated receptors: promising targets for cancer therapy?
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28 September 2017
A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis
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PubMed Central
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28 September 2017
Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis
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PubMed Central
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28 September 2017
Targeting melanoma growth and metastasis with systemic delivery of liposome-incorporated protease-activated receptor-1 small interfering RNA.
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28 September 2017
Melanoma and the tumor microenvironment
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
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28 September 2017
Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
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28 September 2017
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
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28 September 2017
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Amplification of MMP-2 and MMP-9 production by prostate cancer cell lines via activation of protease-activated receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
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28 September 2017
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Tissue factor, thrombin, and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 September 2017
Overexpression of protease-activated receptor-1 contributes to melanoma metastasis via regulation of connexin 43.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
31 May 2018
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
31 May 2018
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
31 May 2018
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 November 2018
The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 November 2018
Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206157
retrieved
28 November 2018
Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22009534
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22009534
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
High prevalence and risk factors of thromboembolism in stage IV melanoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22009534
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/0008-5472.CAN-11-1432
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
203399
OpenCitations bibliographic resource ID
203399
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
203399
PMC publication ID
3206157
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
203399
PubMed publication ID
22009534
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
203399
ResearchGate publication ID
51727315
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