(Q27003902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Reversing T cell immunosenescence: why, who, and how (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Richard Aspinall

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Sheila Govind

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

1 reference

26 February 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

35

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

609-620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

24 January 2020

cites work

1 reference

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Osteoporosis, inflammation and ageing

21 March 2017

1 reference

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Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells

21 March 2017

1 reference

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Thymic involution in aging

21 March 2017

1 reference

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The influence of age on T cell generation and TCR diversity

21 March 2017

1 reference

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Pulmonary delivery of interleukin-7 provides efficient and safe delivery to the aging immune system

21 March 2017

1 reference

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Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence

28 September 2017

1 reference

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Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?

28 September 2017

1 reference

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Aging adults and seasonal influenza: does the vitamin d status (h)arm the body?

28 September 2017

1 reference

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Dysregulation of human Toll-like receptor function in aging

28 September 2017

1 reference

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Influenza vaccine responses in older adults

28 September 2017

1 reference

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Impact of age on T cell signaling: a general defect or specific alterations?

28 September 2017

1 reference

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Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience

28 September 2017

1 reference

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Age effects on B cells and humoral immunity in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Persistent viral infections and immune aging

28 September 2017

1 reference

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28 September 2017

1 reference

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Aging, frailty and age-related diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Factors that may impact on immunosenescence: an appraisal

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Immunity in the elderly: the role of the thymus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Redefining chronic viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Immunosenescence and immunogenetics of human longevity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Cytomegalovirus and human immunosenescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Inflammaging as a prodrome to Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Genome-based prediction of common diseases: advances and prospects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Inflammaging as a major characteristic of old people: can it be prevented or cured?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Homeostasis of the naive CD4+ T cell compartment during aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Protein hormones and immunity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus

28 September 2017

1 reference

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Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Cell biology of IL-7, a key lymphotrophin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

The effect of age on the cognate function of CD4+ T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

CD28 extinction in human T cells: altered functions and the program of T-cell senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Thymic output: a bad TREC record

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Demography. Broken limits to life expectancy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Transplantation of thymus tissue in complete DiGeorge syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

The role of telomeres in ageing and cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Doubling of world population unlikely

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Mechanism of V(D)J recombination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Lymphocyte life-span and memory

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts.

31 May 2018

1 reference

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Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Age-associated thymic atrophy is not associated with a deficiency in the CD44(+)CD25(-)CD3(-)CD4(-)CD8(-) thymocyte population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

In vitro generation of T lymphocytes from embryonic stem cell–derived prehematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

An IL-7 fusion protein that shows increased thymopoietic ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Decline of T cell-related immune functions in cancer patients and an attempt to restore them through infusion of activated autologous T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

B lymphocyte development in rabbit: progenitor B cells and waning of B lymphopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Post-thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Real time-PCR assay estimating the naive T-cell pool in whole blood and dried blood spot samples: pilot study in young adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

The role of the T cell in age-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Tracing thymic output in older individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

IL-7 gene therapy in aging restores early thymopoiesis without reversing involution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

The aging of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Estimating human age from T-cell DNA rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Aging, immunity, and cancer

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3636382

Diversity and structure of genes of the α family of mouse T-cell antigen receptor

28 November 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Changes in thymic function with age and during the treatment of HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11357-012-9393-Y

Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells

21 January 2018

1 reference

12 December 2020

Chronic B cell deficiency from birth prevents age-related alterations in the B lineage

1 reference

12 December 2020

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

1 reference

12 December 2020

Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency

1 reference

12 December 2020

Age-associated thymic atrophy is linked to a decline in IL-7 production

1 reference

12 December 2020

Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

1 reference

12 December 2020

Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

1 reference

12 December 2020

In vitro models of T cell development

1 reference

12 December 2020

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

1 reference

12 December 2020

The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age

1 reference

12 December 2020

A simple method for the measurement of sjTREC levels in blood

1 reference

12 December 2020

Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network

1 reference

12 December 2020

Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy

1 reference

12 December 2020

Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments

1 reference

12 December 2020

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

1 reference

12 December 2020

Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation

1 reference

12 December 2020

10.1007/S11357-012-9393-Y

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

22367580

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367580%20AND%20SRC:MED&resulttype=core&format=json