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Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium
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title
Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium
(English)
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author name string
R. L. Moss
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1
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D. P. Fitzsimons
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2
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J. C. Ralphe
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3
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language of work or name
English
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publication date
2 January 2015
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published in
Circulation Research
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PubMed
volume
116
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PubMed
issue
1
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PubMed
page(s)
183-92
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PubMed
cites work
Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?
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Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C
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21 March 2017
Cardiac myosin binding protein C
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PubMed Central
reference URL
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21 March 2017
Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium
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A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function
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21 March 2017
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling
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21 March 2017
Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium
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21 March 2017
Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C
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21 March 2017
In vivo left ventricular functional capacity is compromised in cMyBP-C null mice
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Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening
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Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament
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A new protein of the thick filaments of vertebrate skeletal myofibrils. Extractions, purification and characterization
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21 March 2017
Determination of the critical residues responsible for cardiac myosin binding protein C's interactions
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PubMed Central
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21 March 2017
Cardiac myosin-binding protein-C phosphorylation and cardiac function
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PubMed Central
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21 March 2017
Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle
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21 March 2017
The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM).
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28 September 2017
Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner
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PubMed Central
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28 September 2017
Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism
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PubMed Central
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28 September 2017
Earning stripes: myosin binding protein-C interactions with actin
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PubMed Central
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28 September 2017
Molecular modulation of actomyosin function by cardiac myosin-binding protein C.
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PubMed Central
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28 September 2017
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.
1 reference
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PubMed Central
reference URL
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28 September 2017
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin
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PubMed Central
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28 September 2017
Characterization of the cardiac myosin binding protein-C phosphoproteome in healthy and failing human hearts
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PubMed Central
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28 September 2017
Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner.
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PubMed Central
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28 September 2017
Molecular mechanics of cardiac myosin-binding protein C in native thick filaments
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PubMed Central
reference URL
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28 September 2017
Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
Structure, interactions and function of the N-terminus of cardiac myosin binding protein C (MyBP-C): who does what, with what, and to whom?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
Myosin binding protein-C: an essential protein in skeletal and cardiac muscle
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
Myosin binding protein C interaction with actin: characterization and mapping of the binding site
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PubMed Central
reference URL
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28 September 2017
Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.
1 reference
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PubMed Central
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28 September 2017
Calcium cycling and signaling in cardiac myocytes.
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28 September 2017
PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo
1 reference
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PubMed Central
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28 September 2017
Cooperativity in the regulation of force and the kinetics of force development in heart and skeletal muscles: cross-bridge activation of force
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PubMed Central
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28 September 2017
Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle
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PubMed Central
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28 September 2017
Myosin crossbridge activation of cardiac thin filaments: implications for myocardial function in health and disease
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28 September 2017
The Genetic Basis for Cardiomyopathy
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28 September 2017
Rate constant of muscle force redevelopment reflects cooperative activation as well as cross-bridge kinetics
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PubMed Central
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28 September 2017
The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 September 2017
Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998
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28 September 2017
Phosphorylation of C-protein in intact amphibian cardiac muscle. Correlation between 32P incorporation and twitch relaxation
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28 September 2017
Structure of C protein purified from cardiac muscle
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PubMed Central
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28 September 2017
Regulation of binding of subfragment 1 in isolated rigor myofibrils
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PubMed Central
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28 September 2017
The binding of skeletal muscle C-protein to F-actin, and its relation to the interaction of actin with myosin subfragment-1
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28 September 2017
Functional dissection of myosin binding protein C phosphorylation
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PubMed Central
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31 May 2018
The contribution of cardiac myosin binding protein-c Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility
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28 November 2018
Sarcomere-length dependence of myosin filament structure in skeletal muscle fibres of the frog.
1 reference
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28 November 2018
Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeletal muscle.
1 reference
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28 November 2018
Activation of myocardial contraction by the N-terminal domains of myosin binding protein-C.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283578
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28 November 2018
Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy
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PubMed Central
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28 November 2018
Myofilament kinetics in isometric twitch dynamics.
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28 November 2018
C-protein limits shortening velocity of rabbit skeletal muscle fibres at low levels of Ca2+ activation
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PubMed
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of phosphorylation of troponin I and C protein on isometric tension and velocity of unloaded shortening in skinned single cardiac myocytes from rats
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/25552695
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25552695
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein kinase A-mediated acceleration of the stretch activation response in murine skinned myocardium is eliminated by ablation of cMyBP-C
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25552695
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges
1 reference
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PubMed
reference URL
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25552695
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1161/CIRCRESAHA.116.300561
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3527266
OpenCitations bibliographic resource ID
3527266
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3527266
PMCID
4283578
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3527266
PubMed ID
25552695
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3527266
ResearchGate publication ID
270343175
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