(Q27012236)

English

Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

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scholarly article

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Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma (English)

0 references

1 reference

based on heuristic

inferred from title

invasive ductal carcinoma

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based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

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based on heuristic

inferred from title

pancreatic ductal carcinoma

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based on heuristic

inferred from title

author name string

Dong Tang

1

1 reference

Daorong Wang

2

1 reference

Zhongxu Yuan

3

1 reference

Xiaofeng Xue

4

1 reference

Ye Zhang

5

1 reference

Yong An

6

1 reference

Jianmin Chen

7

1 reference

Min Tu

8

1 reference

Zipeng Lu

9

1 reference

Jishu Wei

10

1 reference

Kuirong Jiang

11

1 reference

Yi Miao

12

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language of work or name

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publication date

1 March 2013

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International Journal of Cancer

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132

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993-1003

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5

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Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group

1 reference

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21 January 2018

Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

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21 January 2018

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic cancer microenvironment

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Hallmarks of Cancer: The Next Generation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Role of pancreatic stellate cells in pancreatic cancer metastasis.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Identification, culture, and characterization of pancreatic stellate cells in rats and humans.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Molecular regulation of pancreatic stellate cell function

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Analysis of the human pancreatic stellate cell secreted proteome

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells: partners in crime with pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells--role in pancreas cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic cancer: the role of pancreatic stellate cells in tumor progression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The pancreatic stellate cell: a star on the rise in pancreatic diseases

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Molecular pathogenesis of pancreatic cancer and clinical perspectives

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Mechanisms of disease: chronic inflammation and cancer in the pancreas--a potential role for pancreatic stellate cells?

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Risk factors for pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatitis as a risk for pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The fibrosis of chronic pancreatitis: new insights into the role of pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Signal transduction in pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Chronic pancreatitis and pancreatic cancer: prediction and mechanism

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Invasive potential induced under long-term oxidative stress in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Radical causes of cancer.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Immunity, Inflammation, and Cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The multifaceted role of periostin in tumorigenesis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Metastasis: from dissemination to organ-specific colonization

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Epithelial-mesenchymal transitions in development and disease

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

EMT and dissemination precede pancreatic tumor formation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

TGF-beta signaling preserves RECK expression in activated pancreatic stellate cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Role of Ras signaling in the induction of snail by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Desmoplasia of pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The physics of cancer: the role of physical interactions and mechanical forces in metastasis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Putting tumours in context

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Melatonin prevents human pancreatic carcinoma cell PANC-1-induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic tumor growth is regulated by the balance between positive and negative modulators of angiogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pathophysiological consequences of VEGF-induced vascular permeability

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Endogenous inhibitors of angiogenesis: a historical review

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Modulation of the antitumor immune response by complement

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor metastasis: molecular insights and evolving paradigms

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Cell migration: a novel aspect of pancreatic stellate cell biology

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Hepatic and pancreatic stellate cells in focus

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

The metastatic niche: adapting the foreign soil

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Preparing the "soil": the premetastatic niche

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Heparin-binding EGF-like growth factor is an early response gene to chemotherapy and contributes to chemotherapy resistance

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Targeting hypoxia in cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

StellaTUM: current consensus and discussion on pancreatic stellate cell research

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Novel Agents Aiming at Specific Molecular Targets Increase Chemosensitivity and Overcome Chemoresistance in Hematopoietic Malignancies

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1002%2FIJC.27715

21 January 2018

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