(Q27021189)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

2 October 2023

Neuroprotective properties of citicoline: facts, doubts and unresolved issues (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

12 November 2019

neuroprotective agent

1 reference

26 January 2021

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

language of work or name

1 reference

1 March 2014

6 references

17 September 2019

7 November 2019

12 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

26 January 2021

2 October 2023

7 references

17 September 2019

7 November 2019

12 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

26 January 2021

2 October 2023

28

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

issue

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

page(s)

185-193

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 2.5 Generic

7 March 2020

copyright license

start time

7 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Choline and betaine intake and the risk of colorectal cancer in men

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Choline metabolism and risk of breast cancer in a population-based study

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

CDP-choline: pharmacological and clinical review

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Retrospective and observational study to assess the efficacy of citicoline in elderly patients suffering from stupor related to complex geriatric syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Probably role of citicoline in stroke rehabilitation: review of the literature.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

CDP-choline as a biological supplement during neurorecovery: a focused review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Neuroprotection and recovery: recent data at the bench on citicoline.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline in vascular cognitive impairment and vascular dementia after stroke

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline, use in cognitive decline: vascular and degenerative

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

MAPK signal specificity: the right place at the right time

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Effect of oral CDP-choline on plasma choline and uridine levels in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

28 September 2017

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Evidence that 5'-cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Intestinal absorption of cytidine diphosphate choline and its changes in the digestive tract

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

How effective is citicoline for acute ischaemic stroke?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Mechanism of action CDP-choline in parkinsonism.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Transport and metabolism of double-labelled CDPcholine in mammalian tissues.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Effect of CDP-choline on hypocapnic neurons in culture.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Biochemical rationale for the use of CDPcholine in traumatic brain injury: pharmacokinetics of the orally administered drug.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

Highly saturated endonuclear phosphatidylcholine is synthesized in situ and colocated with CDP-choline pathway enzymes

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

The cytidine diphosphate choline content of rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Scientific Opinion on safety and efficacy of choline chloride as a feed additive for all animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Effective treatment of traumatic brain injury: learning from experience.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Evidence of the neuroprotective role of citicoline in glaucoma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Citicoline treatment increases retinal dopamine content in rabbits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Citicoline has a protective effect on damaged retinal ganglion cells in mouse culture retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Action of citicoline on rat retinal expression of extracellular-signal-regulated kinase (ERK1/2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Evidence that 5′-Cytidinediphosphocholine Can Affect Brain Phospholipid Composition by Increasing Choline and Cytidine Plasma Levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40263-014-0144-8

Involvement of the histaminergic system in cytidine 5'-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3933742

28 November 2018

1 reference

12 December 2020

Crystallization of cytidine diphosphate choline from yeast

1 reference

12 December 2020

CDPcholine and CDPethanolamine prevent the release of free fatty acids during brain ischemia

1 reference

12 December 2020

Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia

1 reference

12 December 2020

Choline concentration in normal blood donor and cardiac troponin-positive plasma samples

1 reference

12 December 2020

The level of free choline in plasma

1 reference

12 December 2020

Differential effect of CDP-choline on brain cytosolic choline levels in younger and older subjects as measured by proton magnetic resonance spectroscopy

1 reference

12 December 2020

Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine-5I-diphosphate choline

1 reference

12 December 2020

A rapid LC-ESI-MS/MS method for the quantitation of choline, an active metabolite of citicoline: Application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers

1 reference

12 December 2020

Spectroscopic and molecular modeling studies of the interaction between cytidine and human serum albumin and its analytical application

1 reference

12 December 2020

Citicoline oral solution in glaucoma: is there a role in slowing disease progression?

1 reference

12 December 2020

Stroke: Treatment for acute stroke--the end of the citicoline saga

1 reference

12 December 2020

The enzymatic formation of lecithin from cytidine diphosphate choline and D-1,2-diglyceride

1 reference

12 December 2020

10.1007/S40263-014-0144-8

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 March 2020

1047755148

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

24504829

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24504829%20AND%20SRC:MED&resulttype=core&format=json