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Immunology of AAV-Mediated Gene Transfer in the Eye
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stated in
PubMed
title
Immunology of AAV-Mediated Gene Transfer in the Eye
(English)
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main subject
immunology
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author name string
Keirnan Willett
series ordinal
1
1 reference
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Crossref
Jean Bennett
series ordinal
2
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stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
2013
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stated in
PubMed
published in
Frontiers in Immunology
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Crossref
volume
4
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stated in
PubMed
page(s)
261
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PubMed
cites work
Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration
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PubMed Central
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Vision 1 year after gene therapy for Leber's congenital amaurosis
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PubMed Central
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21 March 2017
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial
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PubMed Central
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Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy
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Safety and efficacy of gene transfer for Leber's congenital amaurosis
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PubMed Central
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21 March 2017
Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness
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21 March 2017
Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
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21 March 2017
Effect of gene therapy on visual function in Leber's congenital amaurosis
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Caspase inhibition with XIAP as an adjunct to AAV vector gene-replacement therapy: improving efficacy and prolonging the treatment window
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AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia
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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
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eyeGENE®: a vision community resource facilitating patient care and paving the path for research through molecular diagnostic testing
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28 September 2017
Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2
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28 September 2017
Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus
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28 September 2017
The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.
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PubMed Central
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28 September 2017
Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.
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28 September 2017
Corneal transduction by intra-stromal injection of AAV vectors in vivo in the mouse and ex vivo in human explants.
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28 September 2017
Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues
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28 September 2017
AAV2 gene therapy readministration in three adults with congenital blindness.
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28 September 2017
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
1 reference
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28 September 2017
Optogenetic therapy for retinitis pigmentosa
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PubMed Central
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28 September 2017
Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years
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PubMed Central
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28 September 2017
Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
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28 September 2017
Vector delivery technique affects gene transfer in the cornea in vivo
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PubMed Central
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28 September 2017
AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa
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PubMed Central
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28 September 2017
Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies
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28 September 2017
Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function
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PubMed Central
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28 September 2017
Molecular anthropology meets genetic medicine to treat blindness in the North African Jewish population: human gene therapy initiated in Israel.
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28 September 2017
AAV serotype influences gene transfer in corneal stroma in vivo.
1 reference
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PubMed Central
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28 September 2017
Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse.
1 reference
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28 September 2017
Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757345
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28 September 2017
Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).
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PubMed Central
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28 September 2017
Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling
1 reference
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28 September 2017
Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757345
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28 September 2017
AAV-mediated tyrosinase gene transfer restores melanogenesis and retinal function in a model of oculo-cutaneous albinism type I (OCA1).
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757345
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28 September 2017
AAV-mediated local delivery of interferon-beta for the treatment of retinoblastoma in preclinical models
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28 September 2017
Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.
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28 September 2017
Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential
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28 September 2017
Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus
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28 September 2017
Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines
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28 September 2017
Adeno-associated viral vectors and the retina
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28 September 2017
Current status of gene delivery and gene therapy in lacrimal gland using viral vectors.
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28 September 2017
Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered.
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28 September 2017
In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration
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28 September 2017
Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir
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28 September 2017
Ocular immune privilege: therapeutic opportunities from an experiment of nature
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28 September 2017
Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes
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28 September 2017
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28 September 2017
Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector.
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31 May 2018
Preclinical safety evaluation of AAV2-sFLT01- a gene therapy for age-related macular degeneration
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31 May 2018
Gene therapy in the second eye of RPE65-deficient dogs improves retinal function
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31 May 2018
Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy
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31 May 2018
Analysis of immune deviation elicited by antigens injected into the subretinal space.
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31 May 2018
In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
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28 November 2018
Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs
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28 November 2018
Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates.
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28 November 2018
Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.
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28 November 2018
Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
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28 November 2018
Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo
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28 November 2018
Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection
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28 November 2018
Effect of late-stage therapy on disease progression in AAV-mediated rescue of photoreceptor cells in the retinoschisin-deficient mouse
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28 November 2018
Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial
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28 November 2018
Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis
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28 November 2018
Highly efficient ex vivo gene delivery into human corneal endothelial cells by recombinant adeno-associated virus
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28 November 2018
Systemic but not intraocular Epo gene transfer protects the retina from light-and genetic-induced degeneration
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28 November 2018
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa
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28 November 2018
A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus
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28 November 2018
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa
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28 November 2018
Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis
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Identifiers
DOI
10.3389/FIMMU.2013.00261
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PMC publication ID
3757345
1 reference
stated in
PubMed
PubMed publication ID
24009613
1 reference
stated in
PubMed
ResearchGate publication ID
256452523
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