(Q27303016)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author

Meritxell Galindo Casas

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Magdalena Dorywalska

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Pavel Strop

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jody A Melton-Witt

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Adela Hasa-Moreno

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Santiago E Farias

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Kathy Delaria

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Victor Lui

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Kris Poulsen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Janette Sutton

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Gary Bolton

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Dahui Zhou

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Ludivine Moine

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Russell Dushin

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Thomas-Toan Tran

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Shu-Hui Liu

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Mathias Rickert

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Davide Foletti

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

David L Shelton

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jaume Pons

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Arvind Rajpal

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

10 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

page(s)

e0132282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

19 February 2020

copyright license

start time

10 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer

21 March 2017

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Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Effect of attachment site on stability of cleavable antibody drug conjugates.

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

28 September 2017

1 reference

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Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering

28 September 2017

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Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma

28 September 2017

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A mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an antibody-drug conjugate (ADC) for treatment of metastatic breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Transglutaminase-based chemo-enzymatic conjugation approach yields homogeneous antibody-drug conjugates.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Site-specific antibody drug conjugates for cancer therapy

28 September 2017

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Drug-conjugated antibodies for the treatment of cancer

28 September 2017

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Antibody-drug conjugates in cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4498778

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

28 September 2017

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Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

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28 September 2017

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Contribution of linker stability to the activities of anticancer immunoconjugates

28 September 2017

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Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

28 September 2017

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Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase

28 September 2017

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Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

31 May 2018

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21 January 2018

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21 January 2018

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Development of potent monoclonal antibody auristatin conjugates for cancer therapy

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26161543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26161543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26161543

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0132282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

26161543

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161543%20AND%20SRC:MED&resulttype=core&format=json