(Q27315944)

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Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23840384%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling (English)

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4 March 2020

Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

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GOA release 2020-03-11

Stephen G. Young

3

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4 March 2020

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Kennen B MacKay

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4 March 2020

Yiping Tu

2

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4 March 2020

Steven G Clarke

4

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4 March 2020

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4 March 2020

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4 March 2020

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4 March 2020

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4 March 2020

e65967

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4 March 2020

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20 June 2013

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

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21 March 2017

Protein kinases and phosphatases in the control of cell fate

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21 March 2017

The structural basis for tight control of PP2A methylation and function by LCMT-1.

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21 March 2017

The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A

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21 March 2017

Identification of PP2A complexes and pathways involved in cell transformation

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21 March 2017

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21 March 2017

Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells

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21 March 2017

The tumor suppressor PP2A Abeta regulates the RalA GTPase

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21 March 2017

Structure of the protein phosphatase 2A holoenzyme

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21 March 2017

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21 March 2017

A gene atlas of the mouse and human protein-encoding transcriptomes

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21 March 2017

Protein measurement with the Folin phenol reagent

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21 March 2017

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21 March 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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21 March 2017

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

1 reference

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21 March 2017

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

1 reference

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21 March 2017

A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

1 reference

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21 March 2017

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

2 references

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21 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

1 reference

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21 March 2017

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

1 reference

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21 March 2017

Serine/threonine phosphatases: mechanism through structure

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21 March 2017

Protein tyrosine phosphatases in the human genome

1 reference

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21 March 2017

Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

1 reference

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21 March 2017

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

21 March 2017

Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Modular evolution of phosphorylation-based signalling systems

1 reference

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28 September 2017

Perspective: Dynamics of receptor tyrosine kinase signaling complexes

1 reference

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28 September 2017

Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

The age of protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Functions of B56-containing PP2As in major developmental and cancer signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Assembly and structure of protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Protein phosphatase 2A regulatory subunits and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Phosphatases at the heart of FoxO metabolic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

SplicePort--an interactive splice-site analysis tool

1 reference

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28 September 2017

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

1 reference

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28 September 2017

The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications

1 reference

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28 September 2017

Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

A new role for protein methylation: switching partners at the phosphatase ball

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 September 2017

Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

31 May 2018

Spatial control of protein phosphatase 2A (de)methylation.

1 reference

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31 May 2018

Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

31 May 2018

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Failure of islet β‐cell compensation for insulin resistance causes type 2 diabetes: What causes non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells

1 reference

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21 January 2018

Depletion of the catalytic subunit of protein phosphatase-2A (PP2Ac) markedly attenuates glucose-stimulated insulin secretion in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Homocysteine induces tau hyperphosphorylation in rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Substrate-specific reduction of PP2A activity exaggerates tau pathology.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0065967

21 January 2018

Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

1 reference

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21 January 2018

[Targeting of PP2A enzymes by viral proteins and cancer signalling].

1 reference

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28 November 2018

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 November 2018

PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: a mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 November 2018

Diagnosis and classification of diabetes mellitus: new criteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 November 2018

Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3688711

28 November 2018

Purification and characterization of an autophosphorylation-activated protein serine threonine kinase that phosphorylates and inactivates protein phosphatase 2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/23840384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0065967

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23840384%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

2013PLoSO...865967M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23840384%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23840384%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

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