(Q27469620)

3 July 2017

title

Genetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and sensitivity of HCV to alpha interferon therapy (English)

1 reference

3 July 2017

0 references

1 reference

1 reference

K Sandres

1

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3 July 2017

M Dubois

2

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3 July 2017

C Pasquier

3

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3 July 2017

J L Payen

4

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3 July 2017

L Alric

5

1 reference

3 July 2017

M Duffaut

6

1 reference

3 July 2017

J P Vinel

7

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3 July 2017

J P Pascal

8

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3 July 2017

J Puel

9

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3 July 2017

J Izopet

10

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3 July 2017

language of work or name

1 reference

1 January 2000

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3 July 2017

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Virology

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3 July 2017

volume

74

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3 July 2017

issue

2

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3 July 2017

page(s)

661-668

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Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B

3 July 2017

cites work

1 reference

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Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase

21 March 2017

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Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy

21 March 2017

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Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

21 March 2017

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NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

21 March 2017

1 reference

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Assessment of hepatitis C virus sequence complexity by electrophoretic mobilities of both single-and double-stranded DNAs

21 March 2017

1 reference

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Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.

21 March 2017

1 reference

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Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations

21 March 2017

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

21 March 2017

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21 March 2017

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Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses

21 March 2017

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Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

21 March 2017

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Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution

21 March 2017

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21 March 2017

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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

21 March 2017

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

21 March 2017

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Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

21 March 2017

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Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis

21 March 2017

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Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group

7 April 2017

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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

7 April 2017

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7 April 2017

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Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization

7 April 2017

1 reference

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Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

7 April 2017

1 reference

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Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections

7 April 2017

1 reference

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Hypervariable region 1 variants act as TCR antagonists for hepatitis C virus-specific CD4+ T cells.

7 April 2017

1 reference

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RNA virus populations as quasispecies.

29 September 2017

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T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.

29 September 2017

1 reference

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Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C.

2 June 2018

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The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus

2 June 2018

1 reference

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Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

2 June 2018

1 reference

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Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C.

2 June 2018

1 reference

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Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

2 June 2018

1 reference

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The treatment of chronic viral hepatitis

2 June 2018

1 reference

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Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy

2 June 2018

1 reference

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Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Characterization of the 5′ noncoding and structural region of the hepatitis C virus genome from patients with non-A, non-B hepatitis responding differently to interferon treatment

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial

2 June 2018

1 reference

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Comparison of 1 or 3 MU of interferon alfa-2b and placebo in patients with chronic non-A, non-B hepatitis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Replication of hepatitis C virus in peripheral blood mononuclear cells. Effect of alpha-interferon therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Genetic complexity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV): influence on the characteristics of the infection and responses to interferon alfa therapy in patients with chronic hepatitis C.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Baseline level and early suppression of serum HCV RNA for predicting sustained complete response to alpha-interferon therapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Assessment of hepatitis C virus quasispecies heterogeneity by gel shift analysis: correlation with response to interferon therapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Humoral immune response to the hypervariable region of hepatitis C virus differs between genotypes 1b and 2a.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Genotype, slow decrease in virus titer during interferon treatment and high degree of sequence variability of hypervariable region are indicative of poor response to interferon treatment in patients with chronic hepatitis type C.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C chronic liver disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=111585

Chronic viral hepatitis--benefits of current therapies

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10623727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis. Le Groupe Français pour l'Etude du Traitement des Hépatites Chroniques NANB/C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10623727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.74.2.661-668.2000

1 reference

3 July 2017

0 references

1 reference