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Identification of Hepatitis C Virus NS5A Inhibitors
scientific article
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scholarly article
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title
Identification of Hepatitis C Virus NS5A Inhibitors
(English)
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main subject
Hepatitis C virus
1 reference
based on heuristic
inferred from title
hepatitis C
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based on heuristic
inferred from title
author name string
Julie A Lemm
series ordinal
1
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Donald O'Boyle
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2
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Mengping Liu
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3
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Peter T Nower
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4
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Richard Colonno
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5
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Milind S Deshpande
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6
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Lawrence B Snyder
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7
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Scott W Martin
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8
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Denis R St Laurent
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9
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Michael H Serrano-Wu
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10
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Jeffrey L Romine
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11
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Nicholas A Meanwell
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12
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Min Gao
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13
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publication date
January 2010
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published in
Journal of Virology
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volume
84
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issue
1
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page(s)
482-91
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cites work
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
A virocidal amphipathic -helical peptide that inhibits hepatitis C virus infection in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
The Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
Effect of alpha interferon on the hepatitis C virus replicon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
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20 March 2017
Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Expression and identification of hepatitis C virus polyprotein cleavage products
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Efficient initiation of HCV RNA replication in cell culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
The lipid droplet is an important organelle for hepatitis C virus production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
20 March 2017
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
7 April 2017
A second hepatitis C virus-encoded proteinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
7 April 2017
Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Hepatitis C virus therapy to date.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Replication-competent chimeric hepatitis C virus subgenomic replicons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
The NS5A protein of hepatitis C virus is a zinc metalloprotein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Hepatitis C virus NS5A: tales of a promiscuous protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
29 September 2017
Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
2 June 2018
Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2798423
retrieved
27 November 2018
Identifiers
DOI
10.1128/JVI.01360-09
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1701905
OpenCitations bibliographic resource ID
1701905
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1701905
PMCID
2798423
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1701905
PubMed ID
19812153
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1701905
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