(Q27548480)

English

Separase YGR098C

fungal protein found in Saccharomyces cerevisiae S288c

separase
YGR098C
ESP1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

peptidase activity

determination method

2 references

cysteine-type endopeptidase activity

determination method

1 reference

1 January 2018

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

cysteine-type peptidase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

protein binding

determination method

4 references

14 February 2019

Molecular mechanism for the regulation of yeast separase by securin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

High-quality binary protein interaction map of the yeast interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

cysteine-type endopeptidase activity

determination method

4 references

14 February 2019

Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

spindle pole body

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

1 January 2018

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

mitotic spindle

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

determination method

1 reference

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

determination method

1 reference

14 February 2019

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

determination method

4 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

7 November 2018

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

determination method

3 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

7 November 2018

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03018&geneProductId=UniProtKB:Q03018

determination method

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

mitotic spindle pole body

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

biological process

regulation of mitotic spindle elongation

determination method

2 references

14 February 2019

The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

14 February 2019

The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

mitotic sister chromatid segregation

determination method

meiotic chromosome separation

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

regulation of exit from mitosis

determination method

determination method

2 references

chromosome segregation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

apoptotic process

determination method

1 reference

14 February 2019

Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

positive regulation of exit from mitosis

determination method

1 reference

14 February 2019

Positive feedback promotes mitotic exit via the APC/C-Cdh1-separase-Cdc14 axis in budding yeast

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03018

determination method

negative regulation of phosphoprotein phosphatase activity

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Sitelinks

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