(Q27549441)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22216

SMAD/FHA domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22216

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22216

Forkhead-associated (FHA) domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

protein serine/threonine/tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

14 February 2019

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

1 reference

10 September 2018

protein binding

16 references

14 February 2019

Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Defining the budding yeast chromatin‐associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

DNA damage signalling targets the kinetochore to promote chromatin mobility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Rad53 FHA Domain Associated with Phosphorylated Rad9 in the DNA Damage Checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Damage-induced phosphorylation of Sld3 is important to block late origin firing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

27 March 2018

27 March 2018

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

27 March 2018

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

cytosol

1 reference

14 February 2019

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

14 February 2019

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

cytoplasm

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

biological process

protein localization

1 reference

14 February 2019

Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

negative regulation of phosphorylation

1 reference

14 February 2019

Inhibition of the mitotic exit network in response to damaged telomeres.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

nucleobase-containing compound metabolic process

IGI

1 reference

14 February 2019

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

IGI

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

1 reference

14 February 2019

peptidyl-serine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

1 reference

27 March 2018

peptidyl-threonine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

1 reference

27 March 2018

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22216&geneProductId=UniProtKB:P22216

1 reference

27 March 2018

signal transduction in response to DNA damage

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

mitotic DNA damage checkpoint signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

protein phosphorylation

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

14 February 2019

14 February 2019

Global analysis of protein phosphorylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22216

HDA

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference