(Q27549756)

P-loop containing nucleoside triphosphate hydrolase

1 reference

Nucleic acid-binding, OB-fold

1 reference

MCM N-terminal domain, protein family

1 reference

AAA proteins

1 reference

MCM OB domain, protein family

1 reference

MCM domain, protein family

1 reference

Mini-chromosome maintenance, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

3'-5' DNA helicase activity

3 references

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

single-stranded DNA binding

1 reference

8 April 2019

Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

DNA helicase activity

1 reference

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

DNA replication origin binding

3 references

8 April 2019

Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

four-way junction helicase activity

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA helicase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

protein binding

8 references

9 May 2019

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

A new MCM modification cycle regulates DNA replication initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

MCM complex binding

1 reference

9 May 2019

Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA replication origin binding

Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

single-stranded 3'-5' DNA helicase activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

cell component

MCM core complex

1 reference

9 May 2019

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA replication preinitiation complex

1 reference

9 May 2019

Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

3 references

9 May 2019

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

replication fork protection complex

1 reference

9 May 2019

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

3 references

8 April 2019

8 April 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

telomere

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

TAS

CMG complex

1 reference

9 May 2019

The architecture of a eukaryotic replisome.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

4 references

9 May 2019

9 May 2019

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

MCM complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

3 references

9 May 2019

9 May 2019

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

1 reference

9 May 2019

silent mating-type cassette heterochromatin assembly

1 reference

9 May 2019

Mcm10 mediates the interaction between DNA replication and silencing machineries

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

1 reference

8 April 2019

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

double-strand break repair via break-induced replication

1 reference

8 April 2019

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA replication initiation

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

nuclear DNA replication

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA unwinding involved in DNA replication

DNA strand elongation involved in DNA replication

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Uninterrupted MCM2-7 function required for DNA replication fork progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

8 April 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

double-strand break repair via break-induced replication

DNA unwinding involved in DNA replication

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA replication initiation

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

DNA strand elongation involved in DNA replication

Uninterrupted MCM2-7 function required for DNA replication fork progression

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38132

has part(s)

MCM N-terminal domain

1 reference

MCM OB domain

1 reference

AAA+ ATPase domain

1 reference

MCM domain

1 reference

Mini-chromosome maintenance, conserved site

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference