(Q27550574)

English

Ferroxidase YDL120W

fungal protein found in Saccharomyces cerevisiae S288c

YFH1
YDL120W
ferroxidase

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ferroxidase activity

determination method

4 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

The ferroxidase activity of yeast frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

oxidoreductase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

iron chaperone activity

determination method

protein binding

determination method

3 references

14 February 2019

Frataxin interacts functionally with mitochondrial electron transport chain proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

2 iron, 2 sulfur cluster binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

identical protein binding

determination method

1 reference

14 February 2019

The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

ferroxidase activity

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

The ferroxidase activity of yeast frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

ferrous iron binding

determination method

3 references

14 February 2019

Monomeric yeast frataxin is an iron-binding protein

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Iron-dependent self-assembly of recombinant yeast frataxin: implications for Friedreich ataxia

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

iron chaperone activity

determination method

3 references

14 February 2019

Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

determination method

4 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

mitochondrial inner membrane

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

mitochondrial intermembrane space

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

mitochondrial matrix

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Yeast and human frataxin are processed to mature form in two sequential steps by the mitochondrial processing peptidase.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

determination method

5 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

7 November 2018

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

7 November 2018

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

determination method

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

The proteome of Saccharomyces cerevisiae mitochondria

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

biological process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

glutathione metabolic process

determination method

1 reference

14 February 2019

Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

cellular iron ion homeostasis

determination method

6 references

16 July 2018

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

YFH1-mediated iron homeostasis is independent of mitochondrial respiration

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

YFH1-mediated iron homeostasis is independent of mitochondrial respiration

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

16 July 2018

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

iron ion homeostasis

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

iron-sulfur cluster assembly

determination method

8 references

14 February 2019

Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

heme biosynthetic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

mitochondrial electron transport, succinate to ubiquinone

determination method

1 reference

14 February 2019

Frataxin interacts functionally with mitochondrial electron transport chain proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

response to oxidative stress

determination method

1 reference

14 February 2019

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

response to iron(II) ion

determination method

1 reference

14 February 2019

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

mitochondrion organization

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

iron incorporation into metallo-sulfur cluster

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

cellular response to oxidative stress

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07540&geneProductId=UniProtKB:Q07540

determination method

cellular iron ion homeostasis

determination method

7 references

14 February 2019

YFH1-mediated iron homeostasis is independent of mitochondrial respiration

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

YFH1-mediated iron homeostasis is independent of mitochondrial respiration

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07540

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

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