(Q27618611)

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

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scholarly article

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8 December 2019

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors (English)

1 reference

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8 December 2019

crystal structure

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Trypanosoma cruzi

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natural product

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8 December 2019

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8 December 2019

William Nigel Hunter

6

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8 December 2019

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Y Zhang

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8 December 2019

M L Cunningham

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8 December 2019

M Berriman

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8 December 2019

publication date

1 January 1999

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8 December 2019

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8 December 2019

7

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8 December 2019

81-89

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8 December 2019

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8 December 2019

The challenge of Chagas' disease chemotherapy: an update of drugs assayed against Trypanosoma cruzi

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Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution

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Metabolism and functions of trypanothione in the Kinetoplastida

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Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

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Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival

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Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

1 reference

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Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity

1 reference

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Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution

1 reference

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X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution

1 reference

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Active site of trypanothione reductase. A target for rational drug design.

1 reference

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The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.

1 reference

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(His)C epsilon-H...O=C < hydrogen bond in the active sites of serine hydrolases

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Cadabicine, an alkaloid from Cadaba farinosa

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

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Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.

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Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.

1 reference

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The CCP4 suite: programs for protein crystallography

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Accurate bond and angle parameters for X-ray protein structure refinement

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Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO

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Improved methods for building protein models in electron density maps and the location of errors in these models

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PROCHECK: a program to check the stereochemical quality of protein structures

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Identifiers

10.1016/S0969-2126(99)80011-2

1 reference

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8 December 2019

1 reference

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8 December 2019

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