(Q27618809)

2

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J Y Huang

3

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L D'Ari

4

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J Rabinowitz

5

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B L Stoddard

The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution

6

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publication date

June 1999

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published in

Protein Science

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volume

8

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issue

6

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page(s)

1342-9

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cites work

1 reference

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

20 March 2017

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

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Cloning and characterization of the Saccharomyces cerevisiae gene encoding NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase.

20 March 2017

1 reference

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Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase enzymes

20 March 2017

1 reference

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Assessment of phase accuracy by cross validation: the free R value. Methods and applications

20 March 2017

1 reference

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Purification, crystallization, and preliminary x-ray studies of a bifunctional 5,10-methenyl/methylene-tetrahydrofolate cyclohydrolase/dehydrogenase from Escherichia coli

7 April 2017

1 reference

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Folic acid and the prevention of birth defects

29 September 2017

1 reference

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Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate

29 September 2017

1 reference

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Formyl-methenyl-methylenetetrahydrofolate synthetase from rabbit liver (combined). Evidence for a single site in the conversion of 5,10-methylenetetrahydrofolate to 10-formyltetrahydrofolate

29 September 2017

1 reference

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Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme

29 September 2017

1 reference

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Flexible ligand docking using a genetic algorithm.

29 September 2017

1 reference

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Substrate flux through methylenetetrahydrofolate dehydrogenase: predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration.

2 June 2018

1 reference

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Expression of active domains of a human folate-dependent trifunctional enzyme in Escherichia coli

2 June 2018

1 reference

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Purification, characterization, cloning, and amino acid sequence of the bifunctional enzyme 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase from Escherichia coli

2 June 2018

1 reference

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Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

2 June 2018

1 reference

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The N-terminal, dehydrogenase/cyclohydrolase domain of yeast cytoplasmic trifunctional C1-tetrahydrofolate synthase requires the C-terminal, synthetase domain for the catalytic activity in vitro

2 June 2018

1 reference

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Kinetic relationships between the various activities of the formyl-methenyl-methylenetetrahydrofolate synthetase.

27 November 2018

1 reference

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Binding and interconversion of tetrahydrofolates at a single site in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase

27 November 2018

1 reference

12 December 2020

Methylenetetrahydrofolate dehydrogenase - methenyltetrahydrofolate cyclohydrolase - formyltetrahydrofolate synthetase from porcine liver: evidence to support a common dehydrogenase-cyclohydrolase site

1 reference

12 December 2020

Homocysteine and vitamins in cardiovascular disease

1 reference

12 December 2020

Evidence for overlapping active sites in a multifunctional enzyme: immunochemical and chemical modification studies on C1-tetrahydrofolate synthase from Saccharomyces cerevisiae

1 reference

12 December 2020

Structural and functional similarities within the coenzyme binding domains of dehydrogenases

1 reference

12 December 2020