(Q27621923)

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The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors

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scholarly article

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The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors (English)

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crystal structure

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author name string

N Y Chirgadze

1

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D J Sall

2

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S L Briggs

3

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D K Clawson

4

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M Zhang

5

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G F Smith

6

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R W Schevitz

7

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publication date

January 2000

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Protein Science

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9

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29-36

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1

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

20 March 2017

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

20 March 2017

Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

20 March 2017

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

20 March 2017

Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

20 March 2017

Thrombin inhibitor design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

2 June 2018

The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2144429

2 June 2018

Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/10739244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/10739244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family of arginal thrombin inhibitors related to efegatran

1 reference

https://pubmed.ncbi.nlm.nih.gov/10739244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10739244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress towards the discovery of orally active thrombin inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10739244

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1110/PS.9.1.29

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