(Q27622531)

1

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J L Pawlitz

2

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K T Moreland

3

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R A Stegeman

4

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W F Hood

5

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J K Gierse

6

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A M Stevens

7

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D C Goodwin

8

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S W Rowlinson

9

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L J Marnett

10

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W C Stallings

11

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R G Kurumbail

12

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language of work or name

English

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publication date

4 May 2000

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number of pages

5

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Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

inferred from page(s)

published in

Nature

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volume

405

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issue

6782

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page(s)

97-101

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cites work

1 reference

7 January 2021

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

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7 January 2021

Cellular regulation of prostaglandin H synthase catalysis

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7 January 2021

Prostaglandin synthase 2.

1 reference

7 January 2021

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

7 January 2021

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1 reference

7 January 2021

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1 reference

7 January 2021

Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2

1 reference

7 January 2021

Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase

1 reference

7 January 2021

Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation

1 reference

7 January 2021

Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms

1 reference

7 January 2021

Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction

1 reference

7 January 2021

Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2

1 reference

7 January 2021

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

1 reference

7 January 2021

The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors

1 reference

7 January 2021

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region

1 reference

7 January 2021

Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX

1 reference

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

7 January 2021

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

1 reference

7 January 2021

Improved Fourier coefficients for maps using phases from partial structures with errors

1 reference

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

7 January 2021

The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s)

1 reference

7 January 2021