(Q27625444)

1

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V Rasetti

2

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J Maibaum

3

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H Rüeger

4

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R Göschke

5

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N C Cohen

6

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S Stutz

7

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F Cumin

8

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W Fuhrer

9

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J M Wood

10

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M G Grütter

The renin-angiotensin system

11

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language of work or name

English

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publication date

July 2000

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published in

Chemistry and Biology

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volume

7

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issue

7

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page(s)

493-504

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cites work

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Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 A resolution

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The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor

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X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins

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High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors

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Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors

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Potent new inhibitors of human renin

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Novel renin inhibitors containing the amino acid statine

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Synthesis and biological activity of some transition-state inhibitors of human renin

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On the size of the active site in proteases. I. Papain

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Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions

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Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors

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Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

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Scaled-up production of recombinant human renin in CHO cells for enzymatic and X-ray structure analysis

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Preliminary crystallographic study of glycosylated recombinant human renin

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