(Q27639422)

5 July 2017

title

A clogged gutter mechanism for protease inhibitors (English)

1 reference

5 July 2017

Evette S Radisky

1

1 reference

5 July 2017

Daniel E Koshland

series ordinal

2

1 reference

5 July 2017

language of work or name

English

0 references

publication date

25 July 2002

1 reference

5 July 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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5 July 2017

volume

99

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5 July 2017

issue

16

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5 July 2017

page(s)

10316-10321

1 reference

High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds

5 July 2017

cites work

1 reference

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Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues

20 March 2017

1 reference

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Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2

20 March 2017

1 reference

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Reactive-site hydrolyzed Cucurbita maxima trypsin inhibitor-V: function, thermodynamic stability, and NMR solution structure

20 March 2017

1 reference

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Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution

20 March 2017

1 reference

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Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo

20 March 2017

1 reference

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Refined crystal structure of the complex of subtilisin BPN' and Streptomyces subtilisin inhibitor at 1.8 A resolution

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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Automated protein model building combined with iterative structure refinement

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

2 references

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20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

22 April 2017

1 reference

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Protein inhibitors of proteinases

20 March 2017

1 reference

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Remarkable phylum selectivity of a Schistocerca gregaria trypsin inhibitor: the possible role of enzyme-inhibitor flexibility

7 April 2017

1 reference

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What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?

29 September 2017

1 reference

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The serine protease inhibitor canonical loop conformation: examples found in extracellular hydrolases, toxins, cytokines and viral proteins.

29 September 2017

1 reference

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Conformational homogeneity in molecular recognition by proteolytic enzymes

29 September 2017

1 reference

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Backbone dynamics of chymotrypsin inhibitor 2: effect of breaking the active site bond and its implications for the mechanism of inhibition of serine proteases

29 September 2017

1 reference

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Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases

29 September 2017

1 reference

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Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Cloning, sequencing, and secretion of Bacillusamyloliquefacienssubtillisin inBacillus subtilis

29 September 2017

1 reference

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Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Mechanisms of temporary inhibition in Streptomyces subtilisin inhibitor induced by an amino acid substitution, tryptophan 86 replaced by histidine

29 September 2017

1 reference

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Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

29 September 2017

1 reference

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Natural protein proteinase inhibitors and their interaction with proteinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

10 Study of protein-protein and of protein-ligand interactions by potentiometric methods

2 June 2018

1 reference

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Recombinant chymotrypsin inhibitor 2: expression, kinetic analysis of inhibition with alpha-chymotrypsin and wild-type and mutant subtilisin BPN', and protein engineering to investigate inhibitory specificity and mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: functional and structural investigation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Internal mobility of reactive-site-hydrolyzed recombinant Cucurbita maxima trypsin inhibitor-V characterized by NMR spectroscopy: evidence for differential stabilization of newly formed C- and N-termini.

2 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Stereochemistry of reaction paths at carbonyl centres

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Binding of the soybean Bowman-Birk proteinase inhibitor and of its chymotrypsin and trypsin inhibiting fragments to bovine α-chymotrypsin and bovine β-trypsin. A thermodynamic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Single peptide bond hydrolysis/resynthesis in squash inhibitors of serine proteinases. 1. Kinetics and thermodynamics of the interaction between squash inhibitors and bovine beta-trypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Analysis of protein–protein interactions by mutagenesis: direct versus indirect effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112332899

Engineering enzyme specificity by "substrate-assisted catalysis"

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124911

Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin

27 November 2018

1 reference

12 December 2020

Variability of the canonical loop conformations in serine proteinases inhibitors and other proteins

1 reference

12 December 2020

Contribution of residues in the reactive site loop of chymotrypsin inhibitor 2 to protein stability and activity

1 reference

12 December 2020

29 Chemical analysis of acylation sites and species

1 reference

12 December 2020

Differential modulation of binding loop flexibility and stability by Arg50 and Arg52 in Cucurbita maxima trypsin inhibitor-V deduced by trypsin-catalyzed hydrolysis and NMR spectroscopy

1 reference

12 December 2020

Association of anhydrotrypsin with the pancreatic trypsin inhibitors

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.112332899

1 reference

5 July 2017

0 references

1 reference

5 July 2017

1 reference