(Q27641928)

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A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme

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A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme (English)

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Christine M Dunham

1

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James B Murray

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2

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William G Scott

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3

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language of work or name

English

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publication date

12 September 2003

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published in

Journal of Molecular Biology

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volume

332

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issue

2

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page(s)

327-36

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cites work

Hammerhead ribozyme kinetics

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7 January 2021

Three-dimensional structure of a hammerhead ribozyme

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7 January 2021

The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage

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https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900843-X

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7 January 2021

A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase

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7 January 2021

Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent cross-links

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7 January 2021

Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme

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7 January 2021

The structural basis of hammerhead ribozyme self-cleavage

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7 January 2021

Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction

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reference URL

https://api.crossref.org/works/10.1016%2FS0022-2836%2803%2900843-X

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7 January 2021

A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction

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7 January 2021

Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate

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7 January 2021

Relationship between internucleotide linkage geometry and the stability of RNA.

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7 January 2021

Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis

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7 January 2021

Ribozyme catalysis via orbital steering

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7 January 2021

Crystal structure of a lead-dependent ribozyme revealing metal binding sites relevant to catalysis

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7 January 2021

Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA

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7 January 2021

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

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7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

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7 January 2021

The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids

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7 January 2021

(Q27641928)

A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme

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