(Q27643825)

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Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificity

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scholarly article

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Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificity (English)

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Drosophila melanogaster

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author name string

Louise Egeblad-Welin

1

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Yonathan Sonntag

2

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Hans Eklund

3

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Birgitte Munch-Petersen

4

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language of work or name

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publication date

March 2007

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274

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1542-51

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6

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Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase

1 reference

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Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants

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Structure and function of cellular deoxyribonucleoside kinases

1 reference

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Structural basis for substrate specificities of cellular deoxyribonucleoside kinases

1 reference

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Structure of human dCK suggests strategies to improve anticancer and antiviral therapy

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The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.

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Structures of thymidine kinase 1 of human and mycoplasmic origin

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Structure of a type II thymidine kinase with bound dTTP

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Purine nucleoside analogues for the treatment of hematological malignancies: pharmacology and clinical applications

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Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants

1 reference

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Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.

1 reference

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Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol

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A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines

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The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue

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Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway: Studies of the Drosophila Deoxyribonucleoside Kinase

1 reference

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Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

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Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme

1 reference

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An approach to multi-copy search in molecular replacement

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Identifiers

10.1111/J.1742-4658.2007.05701.X

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