(Q27644084)

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Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer

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Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer (English)

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Pseudomonas aeruginosa

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author name string

Matthew J Bottomley

1

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Ester Muraglia

2

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Renzo Bazzo

3

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Andrea Carfì

4

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language of work or name

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publication date

4 May 2007

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Journal of Biological Chemistry

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282

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13592-600

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18

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Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators

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Sociomicrobiology: the connections between quorum sensing and biofilms

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The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa

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Lessons from a cooperative, bacterial-animal association: the Vibrio fischeri-Euprymna scolopes light organ symbiosis

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An exclusive contract: specificity in the Vibrio fischeri-Euprymna scolopes partnership.

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Listening in on bacteria: acyl-homoserine lactone signalling

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Cystic fibrosis pathogenesis and the role of biofilms in persistent infection

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Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist

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Cell-to-cell signaling and Pseudomonas aeruginosa infections

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Testing the susceptibility of bacteria in biofilms to antibacterial agents

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Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria

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Quorum sensing: the power of cooperation in the world of Pseudomonas.

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

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P. aeruginosa quorum-sensing systems and virulence

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Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa

1 reference

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LasR, a transcriptional activator of Pseudomonas aeruginosa virulence genes, functions as a multimer

1 reference

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Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR.

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The involvement of cell-to-cell signals in the development of a bacterial biofilm

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Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis

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Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

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Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria.

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Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa

1 reference

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A distinct QscR regulon in the Pseudomonas aeruginosa quorum-sensing circuit

1 reference

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The QscR quorum-sensing regulon of Pseudomonas aeruginosa: an orphan claims its identity

1 reference

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21 January 2018

The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

1 reference

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21 January 2018

Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones

1 reference

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The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

1 reference

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Post-crystallization treatments for improving diffraction quality of protein crystals.

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ARP/wARP and molecular replacement

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Refinement of macromolecular structures by the maximum-likelihood method

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MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

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Protein structure comparison by alignment of distance matrices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils.

1 reference

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21 January 2018

Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

Transcription of quorum-sensing system genes in clinical and environmental isolates of Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700556200

21 January 2018

Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones

1 reference

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21 January 2018

Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor

1 reference

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21 January 2018

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

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Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein.

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Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

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Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

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Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.

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Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

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A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

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21 January 2018

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