(Q27644509)

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Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization (English)
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Andrew J Prongay
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Zhuyan Guo
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Nanhua Yao
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John Pichardo
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Thierry Fischmann
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Joseph Myers
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Patricia C Weber
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Brian M Beyer
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Richard Ingram
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Zhi Hong
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Winifred W Prosise
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Lata Ramanathan
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S Shane Taremi
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Taisa Yarosh-Tomaine
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Rumin Zhang
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Mary Senior
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Rong-Sheng Yang
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Bruce Malcolm
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Ashok Arasappan
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Frank Bennett
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Stephane L Bogen
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Kevin Chen
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Edwin Jao
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Yi-Tsung Liu
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Raymond G Lovey
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Anil K Saksena
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Srikanth Venkatraman
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Viyyoor Girijavallabhan
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F George Njoroge
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Vincent Madison
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17 May 2007
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50
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2310-8
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10
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