(Q27646602)

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Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron−Thioether Coordination Is Stabilized by Hydrophobic Contacts without Increased Inhibitor Potency

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15 January 2020

Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency (English)

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15 January 2020

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Tzanko I Doukov

3

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15 January 2020

Pavel Martásek

4

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15 January 2020

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Jeffrey D Martell

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15 January 2020

Huiying Li

2

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15 January 2020

Linda J Roman

5

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15 January 2020

Michael Soltis

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15 January 2020

Thomas L Poulos

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15 January 2020

Richard B Silverman

8

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15 January 2020

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1 January 2010

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15 January 2020

Journal of the American Chemical Society

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15 January 2020

132

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15 January 2020

2

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15 January 2020

798-806

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15 January 2020

X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors

1 reference

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20 March 2017

Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel

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20 March 2017

Bis-methionyl Coordination in the Crystal Structure of the Heme-binding Domain of the Streptococcal Cell Surface Protein Shp

1 reference

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20 March 2017

Cryoradiolytic reduction of crystalline heme proteins: analysis by UV-Vis spectroscopy and X-ray crystallography

1 reference

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20 March 2017

The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

1 reference

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20 March 2017

Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas

1 reference

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20 March 2017

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

1 reference

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20 March 2017

Structure of cytochrome c551 from Pseudomonas aeruginosa refined at 1.6 Å resolution and comparison of the two redox forms

1 reference

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20 March 2017

High-resolution three-dimensional structure of horse heart cytochrome c

1 reference

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20 March 2017

Oxidation state-dependent conformational changes in cytochrome c

1 reference

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20 March 2017

Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

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20 March 2017

Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

1 reference

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20 March 2017

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

20 March 2017

Heme axial methionine fluxionality in Hydrogenobacter thermophilus cytochrome c552.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

Nitric oxide synthases: properties and catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

The arginine-nitric oxide pathway: a target for new drugs.

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29 September 2017

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

1 reference

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29 September 2017

Nitric oxide (NO): a versatile second messenger in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

Binding of thiols to microsomal cytochrome P-450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

29 September 2017

Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

2 June 2018

Elevated platelet calcium mobilization and nitric oxide synthase activity may reflect abnormalities in schizophrenic brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

2 June 2018

The diverse spectroscopic properties of ferrous cytochrome P-450-CAM ligand complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

2 June 2018

Relationships between seizure activity and cyclic nucleotide levels in brain

1 reference

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2 June 2018

Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

27 November 2018

Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide syntha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

27 November 2018

Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

27 November 2018

Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2826131

27 November 2018

Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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Ligand Binding of Organic Sulfides to Microsomal Cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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The first structurally characterized nitrosyl heme thiolate model complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

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Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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Electronic structure of ferric heme nitrosyl complexes with thiolate coordination

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

based on heuristic

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Sulfur donor ligand binding to ferric cytochrome P-450-CAM and myoglobin. Ultraviolet-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopic investigation of the complexes

1 reference

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12 December 2020

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The generation of a hyperporphyrin spectrum upon thiol binding to ferric chloroperoxidase. Further evidence of endogenous thiolate ligation to the ferric enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

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[25] Nitric-oxide synthase assays

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20014790

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1 reference

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Identifiers

10.1021/JA908544F

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15 January 2020

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15 January 2020

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15 January 2020

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