(Q27650237)

1

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Gopalakrishnan Parthasarathy

2

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Alan D Adams

3

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Soumya Sahoo

4

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Ayesha Sitlani

5

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Carl Sparrow

6

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Jisong Cui

7

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Joseph W Becker

Proceedings of the National Academy of Sciences of the United States of America

8

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language of work or name

English

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publication date

8 April 2008

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published in

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volume

105

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page(s)

5337-42

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issue

14

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cites work

Partial agonists activate PPARgamma using a helix 12 independent mechanism

1 reference

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Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12

20 March 2017

1 reference

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Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

20 March 2017

1 reference

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Structural basis for bile acid binding and activation of the nuclear receptor FXR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

20 March 2017

1 reference

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Bile acids: natural ligands for an orphan nuclear receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Identification of a nuclear receptor for bile acids

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Automated structure solution with autoSHARP

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The nuclear receptor superfamily: the second decade

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The steroid and thyroid hormone receptor superfamily

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Farnesoid X receptor is essential for normal glucose homeostasis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

FXR: a promising target for the metabolic syndrome?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

FXR, a multipurpose nuclear receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Ligand control of coregulator recruitment to nuclear receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Mechanism of the nuclear receptor molecular switch

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Identification of a chemical tool for the orphan nuclear receptor FXR.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Mechanism of corepressor binding and release from nuclear hormone receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Ultrasensitive bioanalytical assays using time-resolved fluorescence detection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2291122

Redundant pathways for negative feedback regulation of bile acid production

29 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

Automatic Solution of Heavy-Atom Substructures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

Modelling prior distributions of atoms for macromolecular refinement and completion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0710981105

Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18391212