(Q27650327)

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Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

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Europe PubMed Central

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5 January 2020

Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid (English)

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5 January 2020

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Patrick Dansette

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5 January 2020

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Guillaume A Schoch

1

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5 January 2020

Jason K Yano

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5 January 2020

Stefaan Sansen

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5 January 2020

C David Stout

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5 January 2020

Eric F Johnson

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15 April 2008

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5 January 2020

Journal of Biological Chemistry

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5 January 2020

283

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5 January 2020

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5 January 2020

17227-17237

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5 January 2020

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

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Examination of 209 drugs for inhibition of cytochrome P450 2C8

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Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes

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Electron-density map interpretation

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7 April 2017

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

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29 September 2017

Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

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Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

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Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

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Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.

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29 September 2017

Spin-state changes in cytochrome P-450cam on binding of specific substrates

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27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

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A low-temperature EPR study of partially purified, soluble ferric cytochromes P-450 and P-448 from rat liver microsomes.

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2 June 2018

Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids

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21 January 2018

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

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Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants

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21 January 2018

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Selective inhibition of human cytochrome P4502C8 by montelukast

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21 January 2018

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21 January 2018

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1 reference

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Cooperativity in Cytochrome P450 3A4

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1 reference

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Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413310

12 December 2020

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In vivo pharmacokinetics of felodipine predicted from in vitro studies in rat, dog and man

1 reference

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12 December 2020

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1 reference

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Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413310

12 December 2020

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1 reference

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12 December 2020

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Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile

1 reference

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1 reference

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12 December 2020

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10.1074/JBC.M802180200

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5 January 2020

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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5 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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