(Q27651958)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

main subject

cell biology

0 references

reactive oxygen species

1 reference

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

author name string

Jun-Qing Du

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Jian Wu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Hua-Jie Zhang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Ya-Hui Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Bei-Ying Qiu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Fang Wu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Jing-Ya Li

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Fa-Jun Nan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Jian-Ping Ding

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Jia Li

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

language of work or name

English

0 references

publication date

2 September 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

13 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

volume

283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

issue

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

page(s)

30205-30215

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis

13 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Caspases: the executioners of apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Emerging roles of caspase-3 in apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Apoptosis in the pathogenesis and treatment of disease

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

The biochemistry of apoptosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

7 April 2017

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

The protein structures that shape caspase activity, specificity, activation and inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Discovery of an allosteric site in the caspases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Method to overcome photoreaction, a serious drawback to the use of dichlorofluorescin in evaluation of reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Apoptosis-based therapies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Molecular aspects of lipoic acid in the prevention of diabetes complications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Caspases are reversibly inactivated by hydrogen peroxide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Potent and selective nonpeptide inhibitors of caspases 3 and 7.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

N-nitrosoanilines: a new class of caspase-3 inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

From bench to clinic with apoptosis-based therapeutic agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Oxidative stress inhibits apoptosis in human lymphoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Genetics of programmed cell death in C. elegans: past, present and future.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

An evolutionary perspective on apoptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Mechanisms and genes of cellular suicide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

Caspases: intracellular signaling by proteolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662080

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Quantitative multiwell myeloid differentiation assay using dichlorodihydrofluorescein diacetate (H2DCF-DA) or dihydrorhodamine 123 (H2R123).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Screening for caspase-3 inhibitors: effect of a reducing agent on identified hit chemotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

KINETIC STUDIES OF GLUTAMIC OXALOACETIC TRANSAMINASE ISOZYMES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Redox properties of protein disulfide isomerase (DsbA) from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Sulfur-centered radical formation from the antioxidant dihydrolipoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

21 January 2018

Apoptosis in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803347200

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

21 January 2018

1 reference

12 December 2020

Isoquinoline-1,3,4-trione and its derivatives attenuate beta-amyloid-induced apoptosis of neuronal cells

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

1 reference

12 December 2020

Disulfiram is a potent inhibitor of proteases of the caspase family

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M803347200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18768468%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference