(Q27655607)

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Small Molecules Bound to Unique Sites in the Target Protein Binding Cleft of Calcium-Bound S100B As Characterized by Nuclear Magnetic Resonance and X-ray Crystallography

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29 January 2020

Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography (English)

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29 January 2020

X-ray crystallography

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Edwin Pozharski

7

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29 January 2020

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29 January 2020

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Thomas H Charpentier

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29 January 2020

Paul T Wilder

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29 January 2020

Melissa A Liriano

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29 January 2020

Kristen M Varney

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29 January 2020

Shijun Zhong

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29 January 2020

Andrew Coop

6

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29 January 2020

Eric A Toth

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29 January 2020

David J Weber

10

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29 January 2020

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1 July 2009

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29 January 2020

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29 January 2020

48

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29 January 2020

26

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29 January 2020

6202-6212

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29 January 2020

Divalent Metal Ion Complexes of S100B in the Absence and Presence of Pentamidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Structural and functional insights into RAGE activation by multimeric S100B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy,

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Intracellular and extracellular roles of S100 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

The S100 protein family: history, function, and expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Ions binding to S100 proteins. I. Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Crystal structures of the helix-loop-helix calcium-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

20 March 2017

Automated and accurate deposition of structures solved by X-ray diffraction to the Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

7 April 2017

Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

7 April 2017

Fragment docking to S100 proteins reveals a wide diversity of weak interaction sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Computational identification of inhibitors of protein-protein interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Calcium-dependent and -independent interactions of the S100 protein family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Design of Inhibitors for S100B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

The multifunctional S100 protein family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Structural changes in the C-terminus of Ca2+-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Ca(2+)-binding proteins S100A6 and S100B in primary cutaneous melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Practical introduction to theory and implementation of multinuclear, multidimensional nuclear magnetic resonance experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

The S100 protein family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

29 September 2017

Inhibition of p53 transcriptional activity by the S100B calcium-binding protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

2 June 2018

The effect of relaxation on the epitope mapping by saturation transfer difference NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

Intracellular Ca2+ and Zn2+ levels regulate the alternative cell density-dependent secretion of S100B in human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

Differential expression of S100 calcium-binding proteins characterizes distinct clinical entities in both WHO grade II and III astrocytic tumours.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

Calcium-dependent interaction of S100B with the C-terminal domain of the tumor suppressor p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

Validation of protein models derived from experiment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

A soluble protein characteristic of the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804263

27 November 2018

S100B protein detection in serum is a significant prognostic factor in metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictive value of serum S100B for monitoring patients with metastatic melanoma during chemotherapy and/or immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of serum S100B detection compared with routine blood parameters in advanced metastatic melanoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1H, 13C and 15N NMR assignments and solution secondary structure of rat Apo-S100 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of serum analyses of S-100 protein beta in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and Zn2+ enhancement of the S100B binding epitope TRTK-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/19469484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI9005754

1 reference

Europe PubMed Central

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

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