(Q27660277)

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Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY

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Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3: SINGLE AMINO ACID NEAR THE ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY (English)

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crystal structure

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3

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7

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Abdellah Allali-Hassani

2

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author name string

Bum Soo Hong

1

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Patrick J Finerty

4

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Farrell Mackenzie

5

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Svetoslav Dimov

6

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Hee-Won Park

8

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language of work or name

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publication date

21 May 2010

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Journal of Biological Chemistry

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285

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21

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16330-40

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Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

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20 March 2017

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

The crystal structure of choline kinase reveals a eukaryotic protein kinase fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Increased choline kinase activity and elevated phosphocholine levels in human colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Pushing the boundaries of molecular replacement with maximum likelihood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

ESPript: analysis of multiple sequence alignments in PostScript

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Structure and function of choline kinase isoforms in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Regulation of phosphatidylcholine biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

20 March 2017

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Alterations of choline phospholipid metabolism in ovarian tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

QSAR of 1,1'-(1,2-ethylenebisbenzyl)bis(4-substitutedpyridinium) dibromides as choline kinase inhibitors: a different approach for antiproliferative drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Choline kinase inhibitors as a novel approach for antiproliferative drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

The actin fold.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Regulation of phosphatidylcholine biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Signaling through phosphatidylcholine breakdown.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

29 September 2017

Probing the active site of YjeE: a vital Escherichia coli protein of unknown function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

2 June 2018

Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

2 June 2018

cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

2 June 2018

Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

2 June 2018

Choline kinase from brewers' yeast. Partial purification, properties, and kinetic mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871500

2 June 2018

Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Choline kinase alpha in cancer prognosis and treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Towards a model for the inhibition of choline kinase by a new type of inhibitor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Structural evolution of the protein kinase-like superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Potential choline kinase inhibitors: a molecular modeling study of bis-quinolinium compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.039024

21 January 2018

Insight into the inhibition of human choline kinase: homology modeling and molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20299452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the effect of two 4-methyl piperidine derivatives of hemicholinium-3, A-4 and A-5, on choline transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/20299452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vitro study of hemicholinium-3 on phospholipid metabolism of Krebs II ascites cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20299452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method

1 reference

https://pubmed.ncbi.nlm.nih.gov/20299452

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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