(Q27666968)

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Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy

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scholarly article

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Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy (English)

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Jean-Pierre Marquette

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5

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7

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author name string

Stefanie Keil

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Hans Matter

2

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Karl Schönafinger

3

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Maike Glien

4

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Silke Haag-Diergarten

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Matthias Urmann

9

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Wolfgang Wendler

10

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publication date

4 April 2011

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6

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4

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633-53

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The metabolic syndrome

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Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes.

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Therapeutic roles of peroxisome proliferator-activated receptor agonists

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PPARs: therapeutic targets for metabolic disease

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PPARs as targets for metabolic and cardiovascular diseases

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Nuclear receptors as potential targets for modulating reverse cholesterol transport

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Nuclear receptors and their relevance to diseases related to lipid metabolism

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PPAR ligands for metabolic disorders

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The PPARs: from orphan receptors to drug discovery

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Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

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The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

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Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

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Peroxisome proliferator-activated receptor γ in diabetes and metabolism

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Thiazolidinediones: a new class of antidiabetic drugs

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

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Activation of PPARdelta alters lipid metabolism in db/db mice.

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21 January 2018

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

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AMPK and PPARdelta agonists are exercise mimetics

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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

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The Protein Data Bank: a computer-based archival file for macromolecular structures

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The Protein Data Bank

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Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

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Atomic Physicochemical Parameters for Three-Dimensional Structure-Directed Quantitative Structure-Activity Relationships I. Partition Coefficients as a Measure of Hydrophobicity

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21 January 2018

Solvent-accessible surfaces of proteins and nucleic acids

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Analytical molecular surface calculation

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

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21 January 2018

QXP: powerful, rapid computer algorithms for structure-based drug design.

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Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

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A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

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Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.

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AMoRe: an automated package for molecular replacement

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Modelling prior distributions of atoms for macromolecular refinement and completion.

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

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21 January 2018

Peroxisome proliferator-activated receptor (PPAR): structure, mechanisms of activation and diverse functions.

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7 January 2021

based on heuristic

inferred from DOI database lookup

A new approach to analysis and display of local lipophilicity/hydrophilicity mapped on molecular surfaces

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100047

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramolecular hydrogen bonding in medicinal chemistry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100047

7 January 2021

based on heuristic

inferred from DOI database lookup

Extending the trend vector: the trend matrix and sample-based partial least squares

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100047

7 January 2021

based on heuristic

inferred from DOI database lookup

Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of ...

1 reference

https://opencitations.net/index/coci/api/v1/citations/10.1021/CI00063A006

12 September 2021

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10.1002/CMDC.201100047

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