(Q27667818)

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Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

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31 January 2020

Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis (English)

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31 January 2020

structural biology

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GOA release 2020-03-11

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31 January 2020

author name string

Zhao Qin Bao

1

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31 January 2020

Douglas M Jacobsen

2

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1 May 2011

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31 January 2020

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31 January 2020

19

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31 January 2020

675-690

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31 January 2020

5

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31 January 2020

Dynamics connect substrate recognition to catalysis in protein kinase A

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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20 March 2017

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1 reference

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20 March 2017

Structural basis of cyclin-dependent kinase activation by phosphorylation

1 reference

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20 March 2017

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

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1 reference

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20 March 2017

Phasercrystallographic software

1 reference

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20 March 2017

Comparison of multiple Amber force fields and development of improved protein backbone parameters

1 reference

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20 March 2017

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

1 reference

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Macromolecular TLS refinement in REFMAC at moderate resolutions

1 reference

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The conformational plasticity of protein kinases

1 reference

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20 March 2017

At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

1 reference

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20 March 2017

Cell cycle kinases in cancer

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Patterns of somatic mutation in human cancer genomes

1 reference

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7 April 2017

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

1 reference

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7 April 2017

Rational design of inhibitors that bind to inactive kinase conformations

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

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7 April 2017

The Protein Data Bank

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7 April 2017

Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

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7 April 2017

A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A.

1 reference

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Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts

1 reference

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1 reference

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1 reference

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Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells

1 reference

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Magnesium and cell cycle control: an update

1 reference

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Why nature chose phosphates

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1 reference

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Detection of conformational changes along the kinetic pathway of protein kinase A using a catalytic trapping technique

1 reference

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2 June 2018

An ATP-linked structural change in protein kinase A precedes phosphoryl transfer under physiological magnesium concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3462661

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2 June 2018

Is there a catalytic base in the active site of cAMP-dependent protein kinase?

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2 June 2018

Requirement for an additional divalent metal cation to activate protein tyrosine kinases.

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27 November 2018

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Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process

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https://pubmed.ncbi.nlm.nih.gov/21565702

12 December 2020

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10.1016/J.STR.2011.02.016

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31 January 2020

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24 November 2022

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21565702%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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31 January 2020

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