(Q27675695)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ* (English)

1 reference

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21 February 2020

0 references

3

1 reference

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21 February 2020

Robert O Messing

6

1 reference

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21 February 2020

author name string

Sivananthaperumal Shanmugasundararaj

1

1 reference

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21 February 2020

Joydip Das

2

1 reference

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21 February 2020

Xiaojuan Zhou

4

1 reference

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21 February 2020

Dan Wang

5

1 reference

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21 February 2020

Karol S Bruzik

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Keith W Miller

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Thilo Stehle

8

1 reference

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21 February 2020

language of work or name

English

0 references

publication date

1 December 2012

1 reference

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21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

103

1 reference

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21 February 2020

issue

11

1 reference

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21 February 2020

page(s)

2331-2340

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

21 February 2020

cites work

1 reference

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Crystal Structure and Allosteric Activation of Protein Kinase C βII

20 March 2017

1 reference

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Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

20 March 2017

1 reference

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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

20 March 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

1 reference

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

20 March 2017

1 reference

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

20 March 2017

1 reference

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Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

20 March 2017

1 reference

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Structural basis for the inhibition of firefly luciferase by a general anesthetic

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Features and development of Coot

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

UCSF Chimera--a visualization system for exploratory research and analysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

1H, 13C and 15N NMR assignments of the C1A and C1B subdomains of PKC-delta

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Crystallographic refinement of ligand complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Emerging molecular mechanisms of general anesthetic action.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Mechanisms of actions of inhaled anesthetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Anaesthetic actions on other targets: protein kinase C and guanine nucleotide-binding proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

The nature of sites of general anaesthetic action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Membrane targeting by C1 and C2 domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Anesthetics and ion channels: molecular models and sites of action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

The packing density in proteins: standard radii and volumes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Inhibition of protein kinase C by alcohols and anaesthetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Effects of halothane and propofol on purified brain protein kinase C activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Stereospecific dihaloalkane binding in a pH-sensitive cavity in cubic insulin crystals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Hydrogen bonding in globular proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Halothane binds in the adenine-specific niche of crystalline adenylate kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Molecular interactions between inhaled anesthetics and proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Interaction of alcohols and anesthetics with protein kinase Calpha.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Binding of xenon to sperm whale myoglobin.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Structural basis for the spectral difference in luciferase bioluminescence.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

The nature of the hydrophobic n-alkanol binding site within the C1 domains of protein kinase Calpha

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Effects of ethanol on protein kinase C activity induced by filamentous actin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Contrasting effects of anesthetics in tadpole bioassays.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Anesthetic cutoff in cycloalkanemethanols. A test of current theories.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514512

Interplay of C1 and C2 domains of protein kinase C-alpha in its membrane binding and activation

27 November 2018

1 reference

12 December 2020

Short hydrogen bonds in proteins

1 reference

12 December 2020

Strong and weak hydrogen bonds in the protein-ligand interface

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Preparation of AB-dinor steroids

1 reference

12 December 2020

Binding of Xenon to Horse Haemoglobin

1 reference

12 December 2020

10.1016/J.BPJ.2012.10.034

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

23283232

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23283232%20AND%20SRC:MED&resulttype=core&format=json