(Q27702125)

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Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis

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Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26356484%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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2 June 2020

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Qingfei Zheng

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2 June 2020

Takayoshi Awakawa

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26356484%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Yan Yan

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2 June 2020

Wen Liu

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2 June 2020

Ikuro Abe

7

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2 June 2020

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2 November 2015

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Angewandte Chemie International Edition

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2 June 2020

54

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2 June 2020

45

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2 June 2020

13462-13465

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2 June 2020

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

1 reference

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21 January 2018

The biosynthetic logic of polyketide diversity

1 reference

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Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

1 reference

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21 January 2018

Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.

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21 January 2018

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome

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21 January 2018

Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

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Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.

1 reference

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21 January 2018

Biosynthesis of polyketide synthase extender units

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201506899

21 January 2018

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

1 reference

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21 January 2018

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

1 reference

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21 January 2018

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

1 reference

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21 January 2018

Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201506899

21 January 2018

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201506899

21 January 2018

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

1 reference

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21 January 2018

Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis.

1 reference

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21 January 2018

Unusual carbon fixation gives rise to diverse polyketide extender units

1 reference

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21 January 2018

Enzymatic synthesis of dilactone scaffold of antimycins

1 reference

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21 January 2018

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility

1 reference

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21 January 2018

De novo biosynthesis of terminal alkyne-labeled natural products.

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21 January 2018

Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.

1 reference

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21 January 2018

Evolutionary history and biotechnological future of carboxylases.

1 reference

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21 January 2018

Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A.

1 reference

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21 January 2018

Identifiers

10.1002/ANIE.201506899

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26356484%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26356484%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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